DOI: 10.1091/mbc.9.10.2963. The Cytoplasmic Zinc Finger Protein ZPR1 Accumulates in the Nucleolus of Proliferating Cells

The Cytoplasmic Zinc Finger Protein ZPR1 Accumulates in the Nucleolus of Proliferating Cells

10.1091/mbc.9.10.2963

Crossref journal-article

American Society for Cell Biology (ASCB)

Molecular Biology of the Cell (1076)

Abstract

The zinc finger protein ZPR1 translocates from the cytoplasm to the nucleus after treatment of cells with mitogens. The function of nuclear ZPR1 has not been defined. Here we demonstrate that ZPR1 accumulates in the nucleolus of proliferating cells. The role of ZPR1 was examined using a gene disruption strategy. Cells lacking ZPR1 are not viable. Biochemical analysis demonstrated that the loss of ZPR1 caused disruption of nucleolar function, including preribosomal RNA expression. These data establish ZPR1 as an essential protein that is required for normal nucleolar function in proliferating cells.

Bibliography

Galcheva-Gargova, Z., Gangwani, L., Konstantinov, K. N., Mikrut, M., Theroux, S. J., Enoch, T., & Davis, R. J. (1998). The Cytoplasmic Zinc Finger Protein ZPR1 Accumulates in the Nucleolus of Proliferating Cells. Molecular Biology of the Cell, 9(10), 2963â2971.

Authors 7

Zoya Galcheva-Gargova (first)
Laxman Gangwani (additional)
Konstantin N. Konstantinov (additional)
Monique Mikrut (additional)
Steven J. Theroux (additional)
Tamar Enoch (additional)
Roger J. Davis (additional)

References 15 Referenced 64

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Dates

Type	When
Created	12 years, 1 month ago (July 2, 2013, 7:12 p.m.)
Deposited	1 year, 3 months ago (May 13, 2024, 1:58 p.m.)
Indexed	11 months, 2 weeks ago (Sept. 4, 2024, 8:43 p.m.)
Issued	26 years, 10 months ago (Oct. 1, 1998)
Published	26 years, 10 months ago (Oct. 1, 1998)
Published Print	26 years, 10 months ago (Oct. 1, 1998)

Funders 0

None

BibTeX

@article{Galcheva_Gargova_1998, title={The Cytoplasmic Zinc Finger Protein ZPR1 Accumulates in the Nucleolus of Proliferating Cells}, volume={9}, ISSN={1939-4586}, url={http://dx.doi.org/10.1091/mbc.9.10.2963}, DOI={10.1091/mbc.9.10.2963}, number={10}, journal={Molecular Biology of the Cell}, publisher={American Society for Cell Biology (ASCB)}, author={Galcheva-Gargova, Zoya and Gangwani, Laxman and Konstantinov, Konstantin N. and Mikrut, Monique and Theroux, Steven J. and Enoch, Tamar and Davis, Roger J.}, editor={Brugge, Joan}, year={1998}, month=oct, pages={2963–2971} }

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