Inosine-5′-Monophosphate Dehydrogenase Is a Rate-determining Factor for p53-dependent Growth Regulation
10.1091/mbc.9.1.15
Crossref journal-article
American Society for Cell Biology (ASCB)
Molecular Biology of the Cell (1076)
Abstract

We have proposed that reduced activity of inosine-5′-monophosphate dehydrogenase (IMPD; IMP:NAD oxidoreductase, EC 1.2.1.14), the rate-limiting enzyme for guanine nucleotide biosynthesis, in response to wild-type p53 expression, is essential for p53-dependent growth suppression. A gene transfer strategy was used to demonstrate that under physiological conditions constitutive IMPD expression prevents p53-dependent growth suppression. In these studies, expression ofbax and waf1, genes implicated in p53-dependent growth suppression in response to DNA damage, remains elevated in response to p53. These findings indicate that under physiological conditions IMPD is a rate-determining factor for p53-dependent growth regulation. In addition, they suggest that theimpd gene may be epistatic to bax andwaf1 in growth suppression. Because of the role of IMPD in the production and balance of GTP and ATP, essential nucleotides for signal transduction, these results suggest that p53 controls cell division signals by regulating purine ribonucleotide metabolism.

Bibliography

Liu, Y., Bohn, S. A., & Sherley, J. L. (1998). Inosine-5′-Monophosphate Dehydrogenase Is a Rate-determining Factor for p53-dependent Growth Regulation. Molecular Biology of the Cell, 9(1), 15–28.

Authors 3
  1. Yuan Liu (first)
  2. Shirley A. Bohn (additional)
  3. James L. Sherley (additional)
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Created 12 years, 1 month ago (July 2, 2013, 7:12 p.m.)
Deposited 3 years, 5 months ago (Feb. 26, 2022, 9:34 p.m.)
Indexed 1 year, 1 month ago (July 4, 2024, 7:53 a.m.)
Issued 27 years, 7 months ago (Jan. 1, 1998)
Published 27 years, 7 months ago (Jan. 1, 1998)
Published Print 27 years, 7 months ago (Jan. 1, 1998)
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@article{Liu_1998, title={Inosine-5′-Monophosphate Dehydrogenase Is a Rate-determining Factor for p53-dependent Growth Regulation}, volume={9}, ISSN={1939-4586}, url={http://dx.doi.org/10.1091/mbc.9.1.15}, DOI={10.1091/mbc.9.1.15}, number={1}, journal={Molecular Biology of the Cell}, publisher={American Society for Cell Biology (ASCB)}, author={Liu, Yuan and Bohn, Shirley A. and Sherley, James L.}, year={1998}, month=jan, pages={15–28} }