DOI: 10.1091/mbc.4.9.897. Proliferating cell nuclear antigen and p21 are components of multiple cell cycle kinase complexes.

Proliferating cell nuclear antigen and p21 are components of multiple cell cycle kinase complexes.

10.1091/mbc.4.9.897

Crossref journal-article

American Society for Cell Biology (ASCB)

Molecular Biology of the Cell (1076)

Abstract

We have recently shown that two proteins, proliferating cell nuclear antigen (PCNA) and p21, are associated with cyclin D. Here we show that PCNA and p21 are common components of a wide variety of cyclin/cyclin-dependent kinase complexes in nontransformed cells. These include kinase complexes containing cyclin A, cyclin B, and cyclin D, associated either with CDC2, CDK2, CDK4, or CDK5. We show that PCNA and p21 form separate quaternary complex with each cyclin/CDK and that these quaternary complexes contain a substantial, if not major, fraction of the cell cycle kinases in asynchronously growing cells. These results suggest that PCNA and p21 may perform a common function for all these kinases.

Bibliography

Zhang, H., Xiong, Y., & Beach, D. (1993). Proliferating cell nuclear antigen and p21 are components of multiple cell cycle kinase complexes. Molecular Biology of the Cell, 4(9), 897â906.

Authors 3

H Zhang (first)
Y Xiong (additional)
D Beach (additional)

References 0 Referenced 261

None

Dates

Type	When
Created	12 years ago (Aug. 16, 2013, 2:59 p.m.)
Deposited	6 years, 1 month ago (July 14, 2019, 8:53 a.m.)
Indexed	2 weeks, 4 days ago (Aug. 5, 2025, 8:26 a.m.)
Issued	31 years, 11 months ago (Sept. 1, 1993)
Published	31 years, 11 months ago (Sept. 1, 1993)
Published Print	31 years, 11 months ago (Sept. 1, 1993)

Funders 0

None

BibTeX

@article{Zhang_1993, title={Proliferating cell nuclear antigen and p21 are components of multiple cell cycle kinase complexes.}, volume={4}, ISSN={1939-4586}, url={http://dx.doi.org/10.1091/mbc.4.9.897}, DOI={10.1091/mbc.4.9.897}, number={9}, journal={Molecular Biology of the Cell}, publisher={American Society for Cell Biology (ASCB)}, author={Zhang, H and Xiong, Y and Beach, D}, year={1993}, month=sep, pages={897–906} }

JSON

{
  "indexed": {
    "date-parts": [
      [
        2025,
        8,
        5
      ]
    ],
    "date-time": "2025-08-05T12:26:33Z",
    "timestamp": 1754396793833
  },
  "reference-count": 0,
  "publisher": "American Society for Cell Biology (ASCB)",
  "issue": "9",
  "content-domain": {
    "domain": [],
    "crossmark-restriction": false
  },
  "published-print": {
    "date-parts": [
      [
        1993,
        9
      ]
    ]
  },
  "abstract": "<jats:p> We have recently shown that two proteins, proliferating cell nuclear antigen (PCNA) and p21, are associated with cyclin D. Here we show that PCNA and p21 are common components of a wide variety of cyclin/cyclin-dependent kinase complexes in nontransformed cells. These include kinase complexes containing cyclin A, cyclin B, and cyclin D, associated either with CDC2, CDK2, CDK4, or CDK5. We show that PCNA and p21 form separate quaternary complex with each cyclin/CDK and that these quaternary complexes contain a substantial, if not major, fraction of the cell cycle kinases in asynchronously growing cells. These results suggest that PCNA and p21 may perform a common function for all these kinases. </jats:p>",
  "DOI": "10.1091/mbc.4.9.897",
  "type": "journal-article",
  "created": {
    "date-parts": [
      [
        2013,
        8,
        16
      ]
    ],
    "date-time": "2013-08-16T18:59:02Z",
    "timestamp": 1376679542000
  },
  "page": "897-906",
  "source": "Crossref",
  "is-referenced-by-count": 261,
  "title": "Proliferating cell nuclear antigen and p21 are components of multiple cell cycle kinase complexes.",
  "prefix": "10.1091",
  "volume": "4",
  "author": [
    {
      "given": "H",
      "family": "Zhang",
      "sequence": "first",
      "affiliation": [
        {
          "name": "Howard Hughes Medical Institute, Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724."
        }
      ]
    },
    {
      "given": "Y",
      "family": "Xiong",
      "sequence": "additional",
      "affiliation": [
        {
          "name": "Howard Hughes Medical Institute, Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724."
        }
      ]
    },
    {
      "given": "D",
      "family": "Beach",
      "sequence": "additional",
      "affiliation": [
        {
          "name": "Howard Hughes Medical Institute, Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724."
        }
      ]
    }
  ],
  "member": "1076",
  "container-title": "Molecular Biology of the Cell",
  "original-title": [],
  "language": "en",
  "deposited": {
    "date-parts": [
      [
        2019,
        7,
        14
      ]
    ],
    "date-time": "2019-07-14T12:53:55Z",
    "timestamp": 1563108835000
  },
  "score": 1,
  "resource": {
    "primary": {
      "URL": "https://www.molbiolcell.org/doi/10.1091/mbc.4.9.897"
    }
  },
  "subtitle": [],
  "short-title": [],
  "issued": {
    "date-parts": [
      [
        1993,
        9
      ]
    ]
  },
  "references-count": 0,
  "journal-issue": {
    "issue": "9",
    "published-print": {
      "date-parts": [
        [
          1993,
          9
        ]
      ]
    }
  },
  "alternative-id": [
    "10.1091/mbc.4.9.897"
  ],
  "URL": "http://dx.doi.org/10.1091/mbc.4.9.897",
  "relation": {},
  "ISSN": [
    "1059-1524",
    "1939-4586"
  ],
  "subject": [],
  "container-title-short": "MBoC",
  "published": {
    "date-parts": [
      [
        1993,
        9
      ]
    ]
  }
}