DOI: 10.1091/mbc.3.10.1117. Inhibition of c-Jun DNA binding by mitogen-activated protein kinase.

Inhibition of c-Jun DNA binding by mitogen-activated protein kinase.

10.1091/mbc.3.10.1117

Crossref journal-article

American Society for Cell Biology (ASCB)

Molecular Biology of the Cell (1076)

Abstract

Here we demonstrate that partially purified Xenopus p42 mitogen-activated protein (MAP) kinase phosphorylates bacterially expressed human c-Jun at a single site, serine 243. Several lines of evidence argue that this phosphorylation is due to p42 MAP kinase itself rather than some contaminating species. Phosphorylation of serine 243 markedly decreases the binding of c-Jun to oligonucleotides containing the 12-O-tetradecanoylphorbol-13-acetate response element. These findings suggest that MAP kinase may play a role in the down-regulation of c-Jun or in the cycle of transcriptional initiation and elongation.

Bibliography

Chou, S. Y., Baichwal, V., & Ferrell, J. E. (1992). Inhibition of c-Jun DNA binding by mitogen-activated protein kinase. Molecular Biology of the Cell, 3(10), 1117â1130.

Authors 3

S Y Chou (first)
V Baichwal (additional)
J E Ferrell (additional)

References 0 Referenced 50

None

Dates

Type	When
Created	12 years ago (Aug. 16, 2013, 2:48 p.m.)
Deposited	6 years, 1 month ago (July 14, 2019, 10:21 a.m.)
Indexed	1 year, 6 months ago (Feb. 21, 2024, 7:28 a.m.)
Issued	32 years, 10 months ago (Oct. 1, 1992)
Published	32 years, 10 months ago (Oct. 1, 1992)
Published Print	32 years, 10 months ago (Oct. 1, 1992)

Funders 0

None

BibTeX

@article{Chou_1992, title={Inhibition of c-Jun DNA binding by mitogen-activated protein kinase.}, volume={3}, ISSN={1939-4586}, url={http://dx.doi.org/10.1091/mbc.3.10.1117}, DOI={10.1091/mbc.3.10.1117}, number={10}, journal={Molecular Biology of the Cell}, publisher={American Society for Cell Biology (ASCB)}, author={Chou, S Y and Baichwal, V and Ferrell, J E}, year={1992}, month=oct, pages={1117–1130} }

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