DOI: 10.1091/mbc.11.8.2631. Thioredoxin Peroxidase Is Required for the Transcriptional Response to Oxidative Stress in Budding Yeast

Thioredoxin Peroxidase Is Required for the Transcriptional Response to Oxidative Stress in Budding Yeast

10.1091/mbc.11.8.2631

Crossref journal-article

American Society for Cell Biology (ASCB)

Molecular Biology of the Cell (1076)

Abstract

A genetic screen was performed in Saccharomyces cerevisiae to identify mechanisms important for the transcriptional activation of genes encoding antioxidant proteins. Thioredoxin peroxidase, Tsa1p, of the thioredoxin system, was found to be essential for the transcriptional induction of other components of the thioredoxin system, TRX2 (thioredoxin) andTRR1 (thioredoxin reductase), in response to H2O2. The expression of TRX2 andTRR1 is known to be regulated by the transcription factors Yap1p and Skn7p in response to H2O2, and the Tsa1p-dependent regulation of TRX2 requires the Yap1p/Skn7p pathway. The data suggest that expression of components of the thioredoxin system is dependent on the activity of Tsa1p in response to H2O2in a Yap1p/Skn7p-dependent pathway.

Bibliography

Ross, S. J., Findlay, V. J., Malakasi, P., & Morgan, B. A. (2000). Thioredoxin Peroxidase Is Required for the Transcriptional Response to Oxidative Stress in Budding Yeast. Molecular Biology of the Cell, 11(8), 2631â2642.

Authors 4

Sarah J. Ross (first)
Victoria J. Findlay (additional)
Panagiota Malakasi (additional)
Brian A. Morgan (additional)

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Dates

Type	When
Created	12 years, 1 month ago (July 2, 2013, 7:57 p.m.)
Deposited	1 year, 3 months ago (May 13, 2024, 2 p.m.)
Indexed	1 year ago (Aug. 5, 2024, 1:16 a.m.)
Issued	25 years ago (Aug. 1, 2000)
Published	25 years ago (Aug. 1, 2000)
Published Print	25 years ago (Aug. 1, 2000)

Funders 0

None

BibTeX

@article{Ross_2000, title={Thioredoxin Peroxidase Is Required for the Transcriptional Response to Oxidative Stress in Budding Yeast}, volume={11}, ISSN={1939-4586}, url={http://dx.doi.org/10.1091/mbc.11.8.2631}, DOI={10.1091/mbc.11.8.2631}, number={8}, journal={Molecular Biology of the Cell}, publisher={American Society for Cell Biology (ASCB)}, author={Ross, Sarah J. and Findlay, Victoria J. and Malakasi, Panagiota and Morgan, Brian A.}, editor={Davis, Trisha N.}, year={2000}, month=aug, pages={2631–2642} }

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