DOI: 10.1091/mbc.10.8.2735. Syntaxin Is Required for Cell Division

10.1091/mbc.10.8.2735

Crossref journal-article

American Society for Cell Biology (ASCB)

Molecular Biology of the Cell (1076)

Abstract

We recently identified a single family member homologue of syntaxin in the sea urchin. Syntaxin is present throughout development, and in rapidly dividing cleavage stage embryos it is present on numerous vesicles at the cell cortex. We hypothesized that syntaxin mediates essential membrane fusion events during early embryogenesis, reasoning that the vesicles and/or their contents are important for development. Here we show that functional inactivation of syntaxin with eitherBotulinum neurotoxin C1, which specifically proteolyzes syntaxin, or antibodies against syntaxin results in an inhibition of cell division. These observations suggest that syntaxin is essential for membrane fusion events critical for cell division.

Bibliography

Conner, S. D., & Wessel, G. M. (1999). Syntaxin Is Required for Cell Division. Molecular Biology of the Cell, 10(8), 2735â2743.

Authors 2

Sean D. Conner (first)
Gary M. Wessel (additional)

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Dates

Type	When
Created	12 years, 1 month ago (July 2, 2013, 7:35 p.m.)
Deposited	3 years, 6 months ago (Feb. 26, 2022, 9:39 p.m.)
Indexed	1 year, 1 month ago (July 25, 2024, 6:31 p.m.)
Issued	26 years ago (Aug. 1, 1999)
Published	26 years ago (Aug. 1, 1999)
Published Print	26 years ago (Aug. 1, 1999)

Funders 0

None

BibTeX

@article{Conner_1999, title={Syntaxin Is Required for Cell Division}, volume={10}, ISSN={1939-4586}, url={http://dx.doi.org/10.1091/mbc.10.8.2735}, DOI={10.1091/mbc.10.8.2735}, number={8}, journal={Molecular Biology of the Cell}, publisher={American Society for Cell Biology (ASCB)}, author={Conner, Sean D. and Wessel, Gary M.}, editor={Helenius, Ari}, year={1999}, month=aug, pages={2735–2743} }

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  "references-count": 46,
  "journal-issue": {
    "issue": "8",
    "published-print": {
      "date-parts": [
        [
          1999,
          8
        ]
      ]
    }
  },
  "alternative-id": [
    "10.1091/mbc.10.8.2735"
  ],
  "URL": "http://dx.doi.org/10.1091/mbc.10.8.2735",
  "relation": {},
  "ISSN": [
    "1059-1524",
    "1939-4586"
  ],
  "subject": [],
  "container-title-short": "MBoC",
  "published": {
    "date-parts": [
      [
        1999,
        8
      ]
    ]
  }
}