DOI: 10.1091/mbc.01-10-0514. Targeting of Rough Endoplasmic Reticulum Membrane Proteins and Ribosomes in Invertebrate Neurons

Targeting of Rough Endoplasmic Reticulum Membrane Proteins and Ribosomes in Invertebrate Neurons

10.1091/mbc.01-10-0514

Crossref journal-article

American Society for Cell Biology (ASCB)

Molecular Biology of the Cell (1076)

Abstract

The endoplasmic reticulum (ER) is divided into rough and smooth domains (RER and SER). The two domains share most proteins, but RER is enriched in some membrane proteins by an unknown mechanism. We studied RER protein targeting by expressing fluorescent protein fusions to ER membrane proteins in Caenorhabditis elegans. In several cell types RER and general ER proteins colocalized, but in neurons RER proteins were concentrated in the cell body, whereas general ER proteins were also found in neurites. Surprisingly RER membrane proteins diffused rapidly within the cell body, indicating they are not localized by immobilization. Ribosomes were also concentrated in the cell body, suggesting they may be in part responsible for targeting RER membrane proteins.

Bibliography

Rolls, M. M., Hall, D. H., Victor, M., Stelzer, E. H. K., & Rapoport, T. A. (2002). Targeting of Rough Endoplasmic Reticulum Membrane Proteins and Ribosomes in Invertebrate Neurons. Molecular Biology of the Cell, 13(5), 1778â1791.

Authors 5

Melissa M. Rolls (first)
David H. Hall (additional)
Martin Victor (additional)
Ernst H. K. Stelzer (additional)
Tom A. Rapoport (additional)

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Dates

Type	When
Created	23 years ago (July 26, 2002, 6:19 p.m.)
Deposited	4 years, 3 months ago (May 17, 2021, 11:36 a.m.)
Indexed	3 months, 2 weeks ago (May 3, 2025, 12:27 p.m.)
Issued	23 years, 3 months ago (May 1, 2002)
Published	23 years, 3 months ago (May 1, 2002)
Published Print	23 years, 3 months ago (May 1, 2002)

Funders 0

None

BibTeX

@article{Rolls_2002, title={Targeting of Rough Endoplasmic Reticulum Membrane Proteins and Ribosomes in Invertebrate Neurons}, volume={13}, ISSN={1939-4586}, url={http://dx.doi.org/10.1091/mbc.01-10-0514}, DOI={10.1091/mbc.01-10-0514}, number={5}, journal={Molecular Biology of the Cell}, publisher={American Society for Cell Biology (ASCB)}, author={Rolls, Melissa M. and Hall, David H. and Victor, Martin and Stelzer, Ernst H. K. and Rapoport, Tom A.}, editor={Lippincott-Schwartz, Jennifer}, year={2002}, month=may, pages={1778–1791} }

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