A Genome Scan for Modifiers of Age at Onset in Huntington Disease: The HD MAPS Study
10.1086/378133
Crossref journal-article
Elsevier BV
The American Journal of Human Genetics (78)
Bibliography

Li, J.-L., Hayden, M. R., Almqvist, E. W., Brinkman, R. R., Durr, A., Dodé, C., Morrison, P. J., Suchowersky, O., Ross, C. A., Margolis, R. L., Rosenblatt, A., Gómez-Tortosa, E., Cabrero, D. M., Novelletto, A., Frontali, M., Nance, M., Trent, R. J. A., McCusker, E., Jones, R., … Myers, R. H. (2003). A Genome Scan for Modifiers of Age at Onset in Huntington Disease: The HD MAPS Study. The American Journal of Human Genetics, 73(3), 682–687.

Authors 39
  1. Jian-Liang Li (first)
  2. Michael R. Hayden (additional)
  3. Elisabeth W. Almqvist (additional)
  4. Ryan R. Brinkman (additional)
  5. Alexandra Durr (additional)
  6. Catherine Dodé (additional)
  7. Patrick J. Morrison (additional)
  8. Oksana Suchowersky (additional)
  9. Christopher A. Ross (additional)
  10. Russell L. Margolis (additional)
  11. Adam Rosenblatt (additional)
  12. Estrella Gómez-Tortosa (additional)
  13. David Mayo Cabrero (additional)
  14. Andrea Novelletto (additional)
  15. Marina Frontali (additional)
  16. Martha Nance (additional)
  17. Ronald J.A. Trent (additional)
  18. Elizabeth McCusker (additional)
  19. Randi Jones (additional)
  20. Jane S. Paulsen (additional)
  21. Madeline Harrison (additional)
  22. Andrea Zanko (additional)
  23. Ruth K. Abramson (additional)
  24. Ana L. Russ (additional)
  25. Beth Knowlton (additional)
  26. Luc Djoussé (additional)
  27. Jayalakshmi S. Mysore (additional)
  28. Suzanne Tariot (additional)
  29. Michael F. Gusella (additional)
  30. Vanessa C. Wheeler (additional)
  31. Larry D. Atwood (additional)
  32. L. Adrienne Cupples (additional)
  33. Marie Saint-Hilaire (additional)
  34. Jang-Ho J. Cha (additional)
  35. Steven M. Hersch (additional)
  36. Walter J. Koroshetz (additional)
  37. James F. Gusella (additional)
  38. Marcy E. MacDonald (additional)
  39. Richard H. Myers (additional)
References 21 Referenced 118
  1. 10.1038/ng0893-398 / Nat Genet / The relationship between trinucleotide (CAG) repeat length and clinical features of Huntington’s disease by Andrew (1993)
  2. {'key': '10.1086/378133_bib6', 'first-page': '1202', 'article-title': 'The likelihood of being affected with Huntington disease by a particular age, for a specific CAG size', 'volume': '60', 'author': 'Brinkman', 'year': '1997', 'journal-title': 'Am J Hum Genet'} / Am J Hum Genet / The likelihood of being affected with Huntington disease by a particular age, for a specific CAG size by Brinkman (1997)
  3. 10.1002/ajmg.a.20190 / Am J Med Genet / Interaction of normal and expanded CAG repeat sizes influences age at onset of Huntington disease by Djoussé (2003)
  4. 10.1038/ng0893-387 / Nat Genet / Trinucleotide repeat length instability and age of onset in Huntington’s disease by Duyao (1993)
  5. {'key': '10.1086/378133_bib9', 'first-page': '125', 'article-title': 'The normal Huntington disease (HD) allele, or a closely linked gene, influences age at onset of HD', 'volume': '53', 'author': 'Farrer', 'year': '1993', 'journal-title': 'Am J Hum Genet'} / Am J Hum Genet / The normal Huntington disease (HD) allele, or a closely linked gene, influences age at onset of HD by Farrer (1993)
  6. {'key': '10.1086/378133_bib10', 'series-title': 'Huntington’s chorea', 'author': 'Hayden', 'year': '1981'} / Huntington’s chorea by Hayden (1981)
  7. {'key': '10.1086/378133_bib11', 'first-page': '317', 'article-title': 'On chorea', 'volume': '26', 'author': 'Huntington', 'year': '1872', 'journal-title': 'Med Surg Reporter'} / Med Surg Reporter / On chorea by Huntington (1872)
  8. 10.1016/0092-8674(93)90585-E / Cell / A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington’s disease chromosomes (1993)
  9. 10.1074/jbc.M103946200 / J Biol Chem / Huntingtin is present in the nucleus, interacts with the transcriptional corepressor C-terminal binding protein, and represses transcription by Kegel (2002)
  10. {'key': '10.1086/378133_bib14', 'first-page': '1347', 'article-title': 'Parametric and nonparametric linkage analysis: a unified multipoint approach', 'volume': '58', 'author': 'Kruglyak', 'year': '1996', 'journal-title': 'Am J Hum Genet'} / Am J Hum Genet / Parametric and nonparametric linkage analysis: a unified multipoint approach by Kruglyak (1996)
  11. 10.1038/ng1195-241 / Nat Genet / Genetic dissection of complex traits: guidelines for interpreting and reporting linkage results by Lander (1995)
  12. 10.1212/WNL.53.6.1330 / Neurology / Evidence for the GluR6 gene associated with younger onset age of Huntington’s disease by MacDonald (1999)
  13. 10.1016/S0304-3940(02)00231-8 / Neurosci Lett / Mutation analysis and association studies of the ubiquitin carboxy-terminal hydrolase L1 gene in Huntington’s disease by Naze (2002)
  14. 10.1086/303029 / Am J Hum Genet / All LODs are not created equal by Nyholt (2000)
  15. 10.1006/mcne.1999.0773 / Mol Cell Neurosci / Nuclear targeting of mutant huntingtin increases toxicity by Peters (1999)
  16. 10.1086/302830 / Am J Hum Genet / Exact multipoint quantitative-trait linkage analysis in pedigrees by variance components by Pratt (2000)
  17. {'key': '10.1086/378133_bib21', 'first-page': '593', 'article-title': 'Anticipation and instability of IT-15 (CAG)n repeats in parent-offspring pairs with Huntington disease', 'volume': '57', 'author': 'Ranen', 'year': '1995', 'journal-title': 'Am J Hum Genet'} / Am J Hum Genet / Anticipation and instability of IT-15 (CAG)n repeats in parent-offspring pairs with Huntington disease by Ranen (1995)
  18. 10.1073/pnas.94.8.3872 / Proc Natl Acad Sci USA / Genotypes at the GluR6 kainate receptor locus are associated with variation in the age of onset of Huntington disease by Rubinsztein (1997)
  19. 10.1016/S0092-8674(00)81782-1 / Cell / Huntingtin acts in the nucleus to induce apoptosis but death does not correlate with the formation of intranuclear inclusions by Saudou (1998)
  20. 10.1038/ng0893-393 / Nat Genet / Relationship between trinucleotide repeat expansion and phenotypic variation in Huntington’s disease by Snell (1993)
  21. {'key': '10.1086/378133_bib25', 'series-title': 'Clinical syndromes in adult neuropsychology: the practitioners handbook', 'first-page': '213', 'article-title': 'Neuropsychology of Huntington’s disease', 'author': 'White', 'year': '1992'} / Clinical syndromes in adult neuropsychology: the practitioners handbook / Neuropsychology of Huntington’s disease by White (1992)
Dates
Type When
Created 22 years ago (Aug. 21, 2003, 8:52 a.m.)
Deposited 6 years, 6 months ago (Feb. 25, 2019, 3:52 a.m.)
Indexed 1 hour, 5 minutes ago (Sept. 2, 2025, 10:42 p.m.)
Issued 22 years ago (Sept. 1, 2003)
Published 22 years ago (Sept. 1, 2003)
Published Print 22 years ago (Sept. 1, 2003)
Funders 0

None

@article{Li_2003, title={A Genome Scan for Modifiers of Age at Onset in Huntington Disease: The HD MAPS Study}, volume={73}, ISSN={0002-9297}, url={http://dx.doi.org/10.1086/378133}, DOI={10.1086/378133}, number={3}, journal={The American Journal of Human Genetics}, publisher={Elsevier BV}, author={Li, Jian-Liang and Hayden, Michael R. and Almqvist, Elisabeth W. and Brinkman, Ryan R. and Durr, Alexandra and Dodé, Catherine and Morrison, Patrick J. and Suchowersky, Oksana and Ross, Christopher A. and Margolis, Russell L. and Rosenblatt, Adam and Gómez-Tortosa, Estrella and Cabrero, David Mayo and Novelletto, Andrea and Frontali, Marina and Nance, Martha and Trent, Ronald J.A. and McCusker, Elizabeth and Jones, Randi and Paulsen, Jane S. and Harrison, Madeline and Zanko, Andrea and Abramson, Ruth K. and Russ, Ana L. and Knowlton, Beth and Djoussé, Luc and Mysore, Jayalakshmi S. and Tariot, Suzanne and Gusella, Michael F. and Wheeler, Vanessa C. and Atwood, Larry D. and Cupples, L. Adrienne and Saint-Hilaire, Marie and Cha, Jang-Ho J. and Hersch, Steven M. and Koroshetz, Walter J. and Gusella, James F. and MacDonald, Marcy E. and Myers, Richard H.}, year={2003}, month=sep, pages={682–687} }