DOI: 10.1085/jgp.84.2.187. Relief of Na+ block of Ca2+-activated K+ channels by external cations.

Relief of Na+ block of Ca2+-activated K+ channels by external cations.

10.1085/jgp.84.2.187

Crossref journal-article

Rockefeller University Press

The Journal of general physiology (291)

Abstract

The flickery block of single Ca2+-activated K+ channels that is produced by internally applied Na+ can be relieved by millimolar concentrations of external K+. This effect of K+ on the kinetics of Na+ block was studied by the method of amplitude distribution analysis described in the companion paper (Yellen, G., 1984b, J. Gen. Physiol., 84:157-186). It appears that K+ relieves block by increasing the exit rate of the blocking ion from the channel, not by competitively slowing its entrance rate. This suggests that a K ion that enters the channel from the outside can expel the blocking Na ion, which entered the channel from the inside. Cs+, which cannot carry current through the channel, and Rb+, which carries a reduced current through the channel, are just as effective as K+ in relieving the block by internal Na+. The kinetics of block by internal nonyltriethylammonium (C9) are unaffected by the presence of these ions in the external bathing solution.

Bibliography

Yellen, G. (1984). Relief of Na+ block of Ca2+-activated K+ channels by external cations. The Journal of General Physiology, 84(2), 187â199.

Authors 1

G Yellen (first)

References 0 Referenced 86

None

Dates

Type	When
Created	21 years, 3 months ago (May 13, 2004, 7:16 p.m.)
Deposited	2 years, 1 month ago (July 27, 2023, 8:15 a.m.)
Indexed	3 months, 3 weeks ago (May 7, 2025, 6:21 p.m.)
Issued	41 years ago (Aug. 1, 1984)
Published	41 years ago (Aug. 1, 1984)
Published Online	41 years ago (Aug. 1, 1984)
Published Print	41 years ago (Aug. 1, 1984)

Funders 0

None

BibTeX

@article{Yellen_1984, title={Relief of Na+ block of Ca2+-activated K+ channels by external cations.}, volume={84}, ISSN={1540-7748}, url={http://dx.doi.org/10.1085/jgp.84.2.187}, DOI={10.1085/jgp.84.2.187}, number={2}, journal={The Journal of general physiology}, publisher={Rockefeller University Press}, author={Yellen, G}, year={1984}, month=aug, pages={187–199} }

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