DOI: 10.1084/jem.87.4.259. CHEMICAL STUDIES IN HOST-VIRUS INTERACTIONS [Penn]

CHEMICAL STUDIES IN HOST-VIRUS INTERACTIONS

10.1084/jem.87.4.259

Crossref journal-article

Rockefeller University Press

Journal of Experimental Medicine (291)

Abstract

Using the one-step growth technique the production of the virus T2 in its host, measured by latent period and burst size, was shown to depend on the nutritional environment of the host cell. When E. coli, grown in broth, was transferred to a simple medium, single organic compounds such as some amino acids and nucleosides were found to increase or accelerate the synthesis of virus. An antimetabolite of glutamic acid, an amino acid important for virus synthesis, was shown to be inhibitory. Several naturally occurring amino acids, leucine, serine, and cysteine, inhibited virus synthesis in the simple medium. A chemically defined mixture was found which supported a rate of virus synthesis very nearly comparable to that found for host cells in nutrient broth.

Bibliography

Fowler, C. B., & Cohen, S. S. (1948). CHEMICAL STUDIES IN HOST-VIRUS INTERACTIONS. Journal of Experimental Medicine, 87(4), 259â274.

Authors 2

Catherine B. Fowler (first)
Seymour S. Cohen (additional)

References 0 Referenced 14

None

Dates

Type	When
Created	21 years, 2 months ago (June 22, 2004, 2:35 p.m.)
Deposited	4 years, 11 months ago (Oct. 3, 2020, 4:35 a.m.)
Indexed	1 month, 3 weeks ago (July 14, 2025, 11:21 p.m.)
Issued	77 years, 5 months ago (April 1, 1948)
Published	77 years, 5 months ago (April 1, 1948)
Published Online	77 years, 5 months ago (April 1, 1948)
Published Print	77 years, 5 months ago (April 1, 1948)

Funders 0

None

BibTeX

@article{Fowler_1948, title={CHEMICAL STUDIES IN HOST-VIRUS INTERACTIONS}, volume={87}, ISSN={0022-1007}, url={http://dx.doi.org/10.1084/jem.87.4.259}, DOI={10.1084/jem.87.4.259}, number={4}, journal={Journal of Experimental Medicine}, publisher={Rockefeller University Press}, author={Fowler, Catherine B. and Cohen, Seymour S.}, year={1948}, month=apr, pages={259–274} }

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