DOI: 10.1084/jem.83.2.97. STUDIES ON THE CHEMICAL NATURE OF THE SUBSTANCE INDUCING TRANSFORMATION OF PNEUMOCOCCAL TYPES

STUDIES ON THE CHEMICAL NATURE OF THE SUBSTANCE INDUCING TRANSFORMATION OF PNEUMOCOCCAL TYPES

10.1084/jem.83.2.97

Crossref journal-article

Rockefeller University Press

Journal of Experimental Medicine (291)

Abstract

1. An improved method is outlined for the isolation and purification of the pneumococcal transforming substance. This method makes use of the fact that citrate inhibits the destructive action of the enzyme, desoxyribonuclease, which is released together with the active material during lysis of the living bacterial cells. A fivefold greater yield of purified transforming agent is obtained by the present method than by the procedure previousiy described. 2. The specific transforming substance has been isolated from pneumococci of types II and VI, in addition to Type III. In each instance the biologically active material has been found to consist of desoxyribonucleic acid.

Bibliography

McCarty, M., & Avery, O. T. (1946). STUDIES ON THE CHEMICAL NATURE OF THE SUBSTANCE INDUCING TRANSFORMATION OF PNEUMOCOCCAL TYPES. Journal of Experimental Medicine, 83(2), 97â104.

Authors 2

Maclyn McCarty (first)
Oswald T. Avery (additional)

References 0 Referenced 91

None

Dates

Type	When
Created	21 years, 2 months ago (June 22, 2004, 2:35 p.m.)
Deposited	4 years, 11 months ago (Oct. 3, 2020, 9:39 a.m.)
Indexed	1 day, 15 hours ago (Sept. 4, 2025, 10:14 a.m.)
Issued	79 years, 7 months ago (Feb. 1, 1946)
Published	79 years, 7 months ago (Feb. 1, 1946)
Published Online	79 years, 7 months ago (Feb. 1, 1946)
Published Print	79 years, 7 months ago (Feb. 1, 1946)

Funders 0

None

BibTeX

@article{McCarty_1946, title={STUDIES ON THE CHEMICAL NATURE OF THE SUBSTANCE INDUCING TRANSFORMATION OF PNEUMOCOCCAL TYPES}, volume={83}, ISSN={0022-1007}, url={http://dx.doi.org/10.1084/jem.83.2.97}, DOI={10.1084/jem.83.2.97}, number={2}, journal={Journal of Experimental Medicine}, publisher={Rockefeller University Press}, author={McCarty, Maclyn and Avery, Oswald T.}, year={1946}, month=feb, pages={97–104} }

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