DOI: 10.1084/jem.50.4.521. CHEMO-IMMUNOLOGICAL STUDIES ON CONJUGATED CARBOHYDRATE-PROTEINS

CHEMO-IMMUNOLOGICAL STUDIES ON CONJUGATED CARBOHYDRATE-PROTEINS

10.1084/jem.50.4.521

Crossref journal-article

Rockefeller University Press

Journal of Experimental Medicine (291)

Abstract

It has been demonstrated that many multiples of minimal doses of Bacillus typhosus reacting factors can be neutralized by specific immune sera. The potency of a given serum can be conveniently titrated against increasing amounts of reacting factors. If the immune serum is diluted or if the amount of the reacting factors is too large for a given amount of serum, there is obtained neutralization but only irregularly. Normal and heterologous sera (therapeutic meningococcus and erysipelas horse sera) free of normal agglutinins or possessing normal agglutinins of a low titer (1:16) for Bacillus typhosus are not able to neutralize the reacting factors. There is obtained questionable neutralization with a serum possessing normal Bacillus typhosus agglutinins in dilution 1:64. The titer of the neutralizing antibodies increases in the course of immunization. Immune sera exercise a definite protection against the mortality induced by intravenous injection of Bacillus typhosus culture filtrates.

Bibliography

Goebel, W. F., & Avery, O. T. (1929). CHEMO-IMMUNOLOGICAL STUDIES ON CONJUGATED CARBOHYDRATE-PROTEINS. Journal of Experimental Medicine, 50(4), 521â531.

Authors 2

Walther F. Goebel (first)
Oswald T. Avery (additional)

References 0 Referenced 170

None

Dates

Type	When
Created	21 years, 2 months ago (June 18, 2004, 2:19 a.m.)
Deposited	4 years, 10 months ago (Oct. 3, 2020, 8:22 a.m.)
Indexed	3 weeks, 2 days ago (Aug. 7, 2025, 4:53 a.m.)
Issued	95 years, 10 months ago (Oct. 1, 1929)
Published	95 years, 10 months ago (Oct. 1, 1929)
Published Online	95 years, 10 months ago (Oct. 1, 1929)
Published Print	95 years, 10 months ago (Oct. 1, 1929)

Funders 0

None

BibTeX

@article{Goebel_1929, title={CHEMO-IMMUNOLOGICAL STUDIES ON CONJUGATED CARBOHYDRATE-PROTEINS}, volume={50}, ISSN={0022-1007}, url={http://dx.doi.org/10.1084/jem.50.4.521}, DOI={10.1084/jem.50.4.521}, number={4}, journal={Journal of Experimental Medicine}, publisher={Rockefeller University Press}, author={Goebel, Walther F. and Avery, Oswald T.}, year={1929}, month=oct, pages={521–531} }

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