DOI: 10.1084/jem.20070590. A functionally specialized population of mucosal CD103+ DCs induces Foxp3+ regulatory T cells via a TGF-β– and retinoic acid

A functionally specialized population of mucosal CD103+ DCs induces Foxp3+ regulatory T cells via a TGF-β– and retinoic acid–dependent mechanism

10.1084/jem.20070590

Crossref journal-article

Rockefeller University Press

The Journal of Experimental Medicine (291)

Abstract

Foxp3+ regulatory T (T reg) cells play a key role in controlling immune pathological re actions. Many develop their regulatory activity in the thymus, but there is also evidence for development of Foxp3+ T reg cells from naive precursors in the periphery. Recent studies have shown that transforming growth factor (TGF)-β can promote T reg cell development in culture, but little is known about the cellular and molecular mechanisms that mediate this pathway under more physiological conditions. Here, we show that after antigen activation in the intestine, naive T cells acquire expression of Foxp3. Moreover, we identify a population of CD103+ mesenteric lymph node dendritic cells (DCs) that induce the devel opment of Foxp3+ T reg cells. Importantly, promotion of T reg cell responses by CD103+ DCs is dependent on TGF-β and the dietary metabolite, retinoic acid (RA). These results newly identify RA as a cofactor in T reg cell generation, providing a mechanism via which functionally specialized gut-associated lymphoid tissue DCs can extend the repertoire of T reg cells focused on the intestine.

Bibliography

Coombes, J. L., Siddiqui, K. R. R., Arancibia-CaÌrcamo, C. V., Hall, J., Sun, C.-M., Belkaid, Y., & Powrie, F. (2007). A functionally specialized population of mucosal CD103+ DCs induces Foxp3+ regulatory T cells via a TGF-Î²â and retinoic acidâdependent mechanism. The Journal of Experimental Medicine, 204(8), 1757â1764.

Authors 7

Janine L. Coombes (first)
Karima R.R. Siddiqui (additional)
Carolina V. Arancibia-Cárcamo (additional)
Jason Hall (additional)
Cheng-Ming Sun (additional)
Yasmine Belkaid (additional)
Fiona Powrie (additional)

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Dates

Type	When
Created	18 years, 1 month ago (July 9, 2007, 8:53 p.m.)
Deposited	2 years, 1 month ago (July 25, 2023, 2:01 p.m.)
Indexed	21 minutes ago (Aug. 29, 2025, 6:17 a.m.)
Issued	18 years, 1 month ago (July 9, 2007)
Published	18 years, 1 month ago (July 9, 2007)
Published Online	18 years, 1 month ago (July 9, 2007)
Published Print	18 years ago (Aug. 6, 2007)

Funders 0

None

BibTeX

@article{Coombes_2007, title={A functionally specialized population of mucosal CD103+ DCs induces Foxp3+ regulatory T cells via a TGF-β– and retinoic acid–dependent mechanism}, volume={204}, ISSN={0022-1007}, url={http://dx.doi.org/10.1084/jem.20070590}, DOI={10.1084/jem.20070590}, number={8}, journal={The Journal of Experimental Medicine}, publisher={Rockefeller University Press}, author={Coombes, Janine L. and Siddiqui, Karima R.R. and Arancibia-Cárcamo, Carolina V. and Hall, Jason and Sun, Cheng-Ming and Belkaid, Yasmine and Powrie, Fiona}, year={2007}, month=jul, pages={1757–1764} }

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