DOI: 10.1084/jem.20061011. Monocytes give rise to mucosal, but not splenic, conventional dendritic cells

Monocytes give rise to mucosal, but not splenic, conventional dendritic cells

10.1084/jem.20061011

Crossref journal-article

Rockefeller University Press

The Journal of Experimental Medicine (291)

Abstract

The mononuclear phagocyte (MP) system is a body-wide macrophage (MΦ) and dendritic cell (DC) network, which contributes to tissue homeostasis, inflammation, and immune defense. The in vivo origins of MPs remain poorly understood. Here, we use an adoptive precursor cell transfer strategy into MP-depleted mice to establish the in vivo differentiation sequence from a recently identified MΦ/DC-restricted bone marrow (BM) precursor (MDP) via BM and blood intermediates to peripheral MΦs and DCs. We show that MDPs are in vivo precursors of BM and blood monocytes. Interestingly, grafted Gr1high “inflammatory” blood monocytes shuttle back to the BM in the absence of inflammation, convert into Gr1low monocytes, and contribute further to MP generation. The grafted monocytes give rise to DCs in the intestinal lamina propria and lung, but not to conventional CD11chigh DCs in the spleen, which develop during homeostasis from MDPs without a monocytic intermediate.

Bibliography

Varol, C., Landsman, L., Fogg, D. K., Greenshtein, L., Gildor, B., Margalit, R., Kalchenko, V., Geissmann, F., & Jung, S. (2006). Monocytes give rise to mucosal, but not splenic, conventional dendritic cells. The Journal of Experimental Medicine, 204(1), 171â180.

Authors 9

Chen Varol (first)
Limor Landsman (additional)
Darin K. Fogg (additional)
Liat Greenshtein (additional)
Boaz Gildor (additional)
Raanan Margalit (additional)
Vyacheslav Kalchenko (additional)
Frederic Geissmann (additional)
Steffen Jung (additional)

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Dates

Type	When
Created	18 years, 8 months ago (Dec. 26, 2006, 8:23 p.m.)
Deposited	2 years, 1 month ago (July 25, 2023, 1:21 p.m.)
Indexed	1 week, 1 day ago (Aug. 24, 2025, 6:52 p.m.)
Issued	18 years, 8 months ago (Dec. 26, 2006)
Published	18 years, 8 months ago (Dec. 26, 2006)
Published Online	18 years, 8 months ago (Dec. 26, 2006)
Published Print	18 years, 7 months ago (Jan. 22, 2007)

Funders 0

None

BibTeX

@article{Varol_2006, title={Monocytes give rise to mucosal, but not splenic, conventional dendritic cells}, volume={204}, ISSN={0022-1007}, url={http://dx.doi.org/10.1084/jem.20061011}, DOI={10.1084/jem.20061011}, number={1}, journal={The Journal of Experimental Medicine}, publisher={Rockefeller University Press}, author={Varol, Chen and Landsman, Limor and Fogg, Darin K. and Greenshtein, Liat and Gildor, Boaz and Margalit, Raanan and Kalchenko, Vyacheslav and Geissmann, Frederic and Jung, Steffen}, year={2006}, month=dec, pages={171–180} }

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