DOI: 10.1084/jem.20042276. TGF-β1 maintains suppressor function and Foxp3 expression in CD4+CD25+ regulatory T cells

TGF-β1 maintains suppressor function and Foxp3 expression in CD4+CD25+ regulatory T cells

10.1084/jem.20042276

Crossref journal-article

Rockefeller University Press

The Journal of Experimental Medicine (291)

Abstract

Transforming growth factor (TGF)-β1 is a major pluripotential cytokine with a pronounced immunosuppressive effect and its deficiency results in lethal autoimmunity in mice. However, mechanisms of its immunosuppressive action are not completely understood. Here, we report that TGF-β1 supports the maintenance of Foxp3 expression, regulatory function, and homeostasis in peripheral CD4+CD25+ regulatory T (T reg) cells, but is not required for their thymic development. We found that in 8–10-d-old TGF-β1–deficient mice, peripheral, but not thymic, T reg cells are significantly reduced in numbers. Moreover, our experiments suggest that a defect in TGF-β–mediated signaling in T reg cells is associated with a decrease in Foxp3 expression and suppressor activity. Thus, our results establish an essential link between TGF-β1 signaling in peripheral T reg cells and T reg cell maintenance in vivo.

Bibliography

Marie, J. C., Letterio, J. J., Gavin, M., & Rudensky, A. Y. (2005). TGF-Î²1 maintains suppressor function and Foxp3 expression in CD4+CD25+ regulatory T cells. The Journal of Experimental Medicine, 201(7), 1061â1067.

Authors 4

Julien C. Marie (first)
John J. Letterio (additional)
Marc Gavin (additional)
Alexander Y. Rudensky (additional)

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Dates

Type	When
Created	20 years, 4 months ago (April 4, 2005, 2:57 p.m.)
Deposited	2 years, 1 month ago (July 25, 2023, 9:03 a.m.)
Indexed	1 week, 6 days ago (Aug. 19, 2025, 6:53 a.m.)
Issued	20 years, 4 months ago (April 4, 2005)
Published	20 years, 4 months ago (April 4, 2005)
Published Online	20 years, 4 months ago (April 4, 2005)
Published Print	20 years, 4 months ago (April 4, 2005)

Funders 0

None

BibTeX

@article{Marie_2005, title={TGF-β1 maintains suppressor function and Foxp3 expression in CD4+CD25+ regulatory T cells}, volume={201}, ISSN={0022-1007}, url={http://dx.doi.org/10.1084/jem.20042276}, DOI={10.1084/jem.20042276}, number={7}, journal={The Journal of Experimental Medicine}, publisher={Rockefeller University Press}, author={Marie, Julien C. and Letterio, John J. and Gavin, Marc and Rudensky, Alexander Y.}, year={2005}, month=apr, pages={1061–1067} }

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