DOI: 10.1084/jem.20021893. CD4+ T Cell Polarization in Mice Is Modulated by Strain-specific Major Histocompatibility Complex–independent Differences within Dendritic Cells

CD4+ T Cell Polarization in Mice Is Modulated by Strain-specific Major Histocompatibility Complex–independent Differences within Dendritic Cells

10.1084/jem.20021893

Crossref journal-article

Rockefeller University Press

The Journal of Experimental Medicine (291)

Abstract

Resistance and susceptibility to Leishmania major in mice are determined by multiple genes and correlate with the preferential development of Th1 and Th2 responses, respectively. Here, we found that CD11b+ dendritic cells (DCs) prime parasite-specific CD4+ T cells in both susceptible BALB/c (H2-d) and resistant B10.D2 (H2-d) mice. However, BALB/c and B10.D2 DCs from L. major–infected mice differ in their ability to polarize naive T cells into Th1 or Th2 effector cells. This difference is cell-intrinsic, is not restricted to H2-d mice, and is observed with both parasite-specific and allospecific CD4+ T cells. Thus, strain-specific differences within CD11b+ DCs influence the ability of inbred mice to mount polarized CD4+ T cell responses.

Bibliography

Filippi, C., Hugues, S., Cazareth, J., Julia, V., Glaichenhaus, N., & Ugolini, S. (2003). CD4+ T Cell Polarization in Mice Is Modulated by Strain-specific Major Histocompatibility Complexâindependent Differences within Dendritic Cells. The Journal of Experimental Medicine, 198(2), 201â209.

Authors 6

Christophe Filippi (first)
Stéphanie Hugues (additional)
Julie Cazareth (additional)
Valérie Julia (additional)
Nicolas Glaichenhaus (additional)
Sophie Ugolini (additional)

References 38 Referenced 81

10.1146/annurev.iy.13.040195.001055 / Annu. Rev. Immunol. (1995)
10.1016/S1074-7613(00)80343-X / Immunity. (1997)
10.1084/jem.185.9.1705 / J. Exp. Med. (1997)
10.1007/978-1-4615-5355-7_8 / Adv. Exp. Med. Biol. (1998)
10.1002/(SICI)1521-4141(199909)29:09<3047::AID-IMMU3047>3.0.CO;2-L / Eur. J. Immunol. (1999)
10.1084/jem.181.3.845 / J. Exp. Med. (1995)
10.1126/science.281.5381.1352 / Science. (1998)
10.4049/jimmunol.159.4.1767 / J. Immunol. (1997)
10.1007/s001090050135 / J. Mol. Med. (1997)
10.4049/jimmunol.162.3.1339 / J. Immunol. (1999)
10.1002/eji.1830220603 / Eur. J. Immunol. (1992)
10.1002/eji.1830230730 / Eur. J. Immunol. (1993)
10.1093/infdis/167.2.418 / J. Infect. Dis. (1993)
10.1084/jem.188.8.1547 / J. Exp. Med. (1998)
10.1002/1521-4141(2000012)30:12<3498::AID-IMMU3498>3.0.CO;2-6 / Eur. J. Immunol. (2000)
10.1016/S1074-7613(00)00075-3 / Immunity. (2000)
10.4049/jimmunol.167.8.4311 / J. Immunol. (2001)
10.1126/science.7725103 / Science. (1995)
10.1126/science.274.5286.421 / Science. (1996)
10.1083/jcb.147.3.599 / J. Cell Biol. (1999)
10.1073/pnas.88.16.7276 / Proc. Natl. Acad. Sci. USA. (1991)
10.1038/35065016 / Nature. (2001)
10.1084/jem.183.3.751 / J. Exp. Med. (1996)
10.1084/jem.185.12.2133 / J. Exp. Med. (1997)
10.1084/jem.188.6.1075 / J. Exp. Med. (1998)
10.4049/jimmunol.167.2.741 / J. Immunol. (2001)
10.1146/annurev.immunol.15.1.297 / Annu. Rev. Immunol. (1997)
10.1038/nri727 / Nat. Rev. Immunol. (2002)
10.4049/jimmunol.154.1.97 / J. Immunol. (1995)
10.1016/0092-8674(95)90349-6 / Cell. (1995)
10.1016/S1074-7613(02)00273-X / Immunity. (2002)
10.1084/jem.20021109 / J. Exp. Med. (2003)
10.1016/S1074-7613(01)00136-4 / Immunity. (2001)
10.1084/jem.179.2.447 / J. Exp. Med. (1994)
10.1002/(SICI)1521-4141(199807)28:07<2066::AID-IMMU2066>3.0.CO;2-X / Eur. J. Immunol. (1998)
10.1084/jem.188.12.2289 / J. Exp. Med. (1998)
10.1126/science.271.5251.984 / Science. (1996)
10.1016/S1286-4579(99)80018-5 / Microbes Infect. (1999)

Dates

Type	When
Created	22 years, 1 month ago (July 14, 2003, 8:31 p.m.)
Deposited	2 years, 1 month ago (July 25, 2023, 8:08 a.m.)
Indexed	2 months, 1 week ago (June 18, 2025, 9:56 p.m.)
Issued	22 years, 1 month ago (July 14, 2003)
Published	22 years, 1 month ago (July 14, 2003)
Published Online	22 years, 1 month ago (July 14, 2003)
Published Print	22 years, 1 month ago (July 21, 2003)

Funders 0

None

BibTeX

@article{Filippi_2003, title={CD4+ T Cell Polarization in Mice Is Modulated by Strain-specific Major Histocompatibility Complex–independent Differences within Dendritic Cells}, volume={198}, ISSN={0022-1007}, url={http://dx.doi.org/10.1084/jem.20021893}, DOI={10.1084/jem.20021893}, number={2}, journal={The Journal of Experimental Medicine}, publisher={Rockefeller University Press}, author={Filippi, Christophe and Hugues, Stéphanie and Cazareth, Julie and Julia, Valérie and Glaichenhaus, Nicolas and Ugolini, Sophie}, year={2003}, month=jul, pages={201–209} }

JSON

{
  "indexed": {
    "date-parts": [
      [
        2025,
        6,
        19
      ]
    ],
    "date-time": "2025-06-19T01:56:25Z",
    "timestamp": 1750298185745
  },
  "reference-count": 38,
  "publisher": "Rockefeller University Press",
  "issue": "2",
  "content-domain": {
    "domain": [
      "rupress.org"
    ],
    "crossmark-restriction": true
  },
  "published-print": {
    "date-parts": [
      [
        2003,
        7,
        21
      ]
    ]
  },
  "abstract": "<jats:p>Resistance and susceptibility to Leishmania major in mice are determined by multiple genes and correlate with the preferential development of Th1 and Th2 responses, respectively. Here, we found that CD11b+ dendritic cells (DCs) prime parasite-specific CD4+ T cells in both susceptible BALB/c (H2-d) and resistant B10.D2 (H2-d) mice. However, BALB/c and B10.D2 DCs from L. major\u2013infected mice differ in their ability to polarize naive T cells into Th1 or Th2 effector cells. This difference is cell-intrinsic, is not restricted to H2-d mice, and is observed with both parasite-specific and allospecific CD4+ T cells. Thus, strain-specific differences within CD11b+ DCs influence the ability of inbred mice to mount polarized CD4+ T cell responses.</jats:p>",
  "DOI": "10.1084/jem.20021893",
  "type": "journal-article",
  "created": {
    "date-parts": [
      [
        2003,
        7,
        15
      ]
    ],
    "date-time": "2003-07-15T00:31:33Z",
    "timestamp": 1058229093000
  },
  "page": "201-209",
  "update-policy": "http://dx.doi.org/10.1084/jem.crossmarkpolicy",
  "source": "Crossref",
  "is-referenced-by-count": 81,
  "title": "CD4+ T Cell Polarization in Mice Is Modulated by Strain-specific Major Histocompatibility Complex\u2013independent Differences within Dendritic Cells",
  "prefix": "10.1084",
  "volume": "198",
  "author": [
    {
      "given": "Christophe",
      "family": "Filippi",
      "sequence": "first",
      "affiliation": [
        {
          "name": "E03-44, Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale, University of Nice-Sophia Antipolis, 06560 Valbonne, France"
        }
      ]
    },
    {
      "given": "Ste\u0301phanie",
      "family": "Hugues",
      "sequence": "additional",
      "affiliation": [
        {
          "name": "E03-44, Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale, University of Nice-Sophia Antipolis, 06560 Valbonne, France"
        }
      ]
    },
    {
      "given": "Julie",
      "family": "Cazareth",
      "sequence": "additional",
      "affiliation": [
        {
          "name": "E03-44, Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale, University of Nice-Sophia Antipolis, 06560 Valbonne, France"
        }
      ]
    },
    {
      "given": "Vale\u0301rie",
      "family": "Julia",
      "sequence": "additional",
      "affiliation": [
        {
          "name": "E03-44, Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale, University of Nice-Sophia Antipolis, 06560 Valbonne, France"
        }
      ]
    },
    {
      "given": "Nicolas",
      "family": "Glaichenhaus",
      "sequence": "additional",
      "affiliation": [
        {
          "name": "E03-44, Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale, University of Nice-Sophia Antipolis, 06560 Valbonne, France"
        }
      ]
    },
    {
      "given": "Sophie",
      "family": "Ugolini",
      "sequence": "additional",
      "affiliation": [
        {
          "name": "E03-44, Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale, University of Nice-Sophia Antipolis, 06560 Valbonne, France"
        }
      ]
    }
  ],
  "member": "291",
  "published-online": {
    "date-parts": [
      [
        2003,
        7,
        14
      ]
    ]
  },
  "reference": [
    {
      "key": "2023072512024898000_BIB1",
      "doi-asserted-by": "crossref",
      "first-page": "151",
      "DOI": "10.1146/annurev.iy.13.040195.001055",
      "volume": "13",
      "year": "1995",
      "journal-title": "Annu. Rev. Immunol."
    },
    {
      "key": "2023072512024898000_BIB2",
      "doi-asserted-by": "crossref",
      "first-page": "551",
      "DOI": "10.1016/S1074-7613(00)80343-X",
      "volume": "6",
      "year": "1997",
      "journal-title": "Immunity."
    },
    {
      "key": "2023072512024898000_BIB3",
      "doi-asserted-by": "crossref",
      "first-page": "1705",
      "DOI": "10.1084/jem.185.9.1705",
      "volume": "185",
      "year": "1997",
      "journal-title": "J. Exp. Med."
    },
    {
      "key": "2023072512024898000_BIB4",
      "doi-asserted-by": "crossref",
      "first-page": "61",
      "DOI": "10.1007/978-1-4615-5355-7_8",
      "volume": "452",
      "year": "1998",
      "journal-title": "Adv. Exp. Med. Biol."
    },
    {
      "key": "2023072512024898000_BIB5",
      "doi-asserted-by": "crossref",
      "first-page": "3047",
      "DOI": "10.1002/(SICI)1521-4141(199909)29:09<3047::AID-IMMU3047>3.0.CO;2-L",
      "volume": "29",
      "year": "1999",
      "journal-title": "Eur. J. Immunol."
    },
    {
      "key": "2023072512024898000_BIB6",
      "doi-asserted-by": "crossref",
      "first-page": "845",
      "DOI": "10.1084/jem.181.3.845",
      "volume": "181",
      "year": "1995",
      "journal-title": "J. Exp. Med."
    },
    {
      "key": "2023072512024898000_BIB7",
      "doi-asserted-by": "crossref",
      "first-page": "1352",
      "DOI": "10.1126/science.281.5381.1352",
      "volume": "281",
      "year": "1998",
      "journal-title": "Science."
    },
    {
      "key": "2023072512024898000_BIB8",
      "doi-asserted-by": "crossref",
      "first-page": "1767",
      "DOI": "10.4049/jimmunol.159.4.1767",
      "volume": "159",
      "year": "1997",
      "journal-title": "J. Immunol."
    },
    {
      "key": "2023072512024898000_BIB9",
      "doi-asserted-by": "crossref",
      "first-page": "502",
      "DOI": "10.1007/s001090050135",
      "volume": "75",
      "year": "1997",
      "journal-title": "J. Mol. Med."
    },
    {
      "key": "2023072512024898000_BIB10",
      "doi-asserted-by": "crossref",
      "first-page": "1339",
      "DOI": "10.4049/jimmunol.162.3.1339",
      "volume": "162",
      "year": "1999",
      "journal-title": "J. Immunol."
    },
    {
      "key": "2023072512024898000_BIB11",
      "doi-asserted-by": "crossref",
      "first-page": "1341",
      "DOI": "10.1002/eji.1830220603",
      "volume": "22",
      "year": "1992",
      "journal-title": "Eur. J. Immunol."
    },
    {
      "key": "2023072512024898000_BIB12",
      "doi-asserted-by": "crossref",
      "first-page": "1595",
      "DOI": "10.1002/eji.1830230730",
      "volume": "23",
      "year": "1993",
      "journal-title": "Eur. J. Immunol."
    },
    {
      "key": "2023072512024898000_BIB13",
      "doi-asserted-by": "crossref",
      "first-page": "418",
      "DOI": "10.1093/infdis/167.2.418",
      "volume": "167",
      "year": "1993",
      "journal-title": "J. Infect. Dis."
    },
    {
      "key": "2023072512024898000_BIB14",
      "doi-asserted-by": "crossref",
      "first-page": "1547",
      "DOI": "10.1084/jem.188.8.1547",
      "volume": "188",
      "year": "1998",
      "journal-title": "J. Exp. Med."
    },
    {
      "key": "2023072512024898000_BIB15",
      "doi-asserted-by": "crossref",
      "first-page": "3498",
      "DOI": "10.1002/1521-4141(2000012)30:12<3498::AID-IMMU3498>3.0.CO;2-6",
      "volume": "30",
      "year": "2000",
      "journal-title": "Eur. J. Immunol."
    },
    {
      "key": "2023072512024898000_BIB16",
      "doi-asserted-by": "crossref",
      "first-page": "771",
      "DOI": "10.1016/S1074-7613(00)00075-3",
      "volume": "13",
      "year": "2000",
      "journal-title": "Immunity."
    },
    {
      "key": "2023072512024898000_BIB17",
      "doi-asserted-by": "crossref",
      "first-page": "4311",
      "DOI": "10.4049/jimmunol.167.8.4311",
      "volume": "167",
      "year": "2001",
      "journal-title": "J. Immunol."
    },
    {
      "key": "2023072512024898000_BIB18",
      "doi-asserted-by": "crossref",
      "first-page": "563",
      "DOI": "10.1126/science.7725103",
      "volume": "268",
      "year": "1995",
      "journal-title": "Science."
    },
    {
      "key": "2023072512024898000_BIB19",
      "doi-asserted-by": "crossref",
      "first-page": "421",
      "DOI": "10.1126/science.274.5286.421",
      "volume": "274",
      "year": "1996",
      "journal-title": "Science."
    },
    {
      "key": "2023072512024898000_BIB20",
      "doi-asserted-by": "crossref",
      "first-page": "599",
      "DOI": "10.1083/jcb.147.3.599",
      "volume": "147",
      "year": "1999",
      "journal-title": "J. Cell Biol."
    },
    {
      "key": "2023072512024898000_BIB21",
      "doi-asserted-by": "crossref",
      "first-page": "7276",
      "DOI": "10.1073/pnas.88.16.7276",
      "volume": "88",
      "year": "1991",
      "journal-title": "Proc. Natl. Acad. Sci. USA."
    },
    {
      "key": "2023072512024898000_BIB22",
      "doi-asserted-by": "crossref",
      "first-page": "50",
      "DOI": "10.1038/35065016",
      "volume": "410",
      "year": "2001",
      "journal-title": "Nature."
    },
    {
      "key": "2023072512024898000_BIB23",
      "doi-asserted-by": "crossref",
      "first-page": "751",
      "DOI": "10.1084/jem.183.3.751",
      "volume": "183",
      "year": "1996",
      "journal-title": "J. Exp. Med."
    },
    {
      "key": "2023072512024898000_BIB24",
      "doi-asserted-by": "crossref",
      "first-page": "2133",
      "DOI": "10.1084/jem.185.12.2133",
      "volume": "185",
      "year": "1997",
      "journal-title": "J. Exp. Med."
    },
    {
      "key": "2023072512024898000_BIB25",
      "doi-asserted-by": "crossref",
      "first-page": "1075",
      "DOI": "10.1084/jem.188.6.1075",
      "volume": "188",
      "year": "1998",
      "journal-title": "J. Exp. Med."
    },
    {
      "key": "2023072512024898000_BIB26",
      "doi-asserted-by": "crossref",
      "first-page": "741",
      "DOI": "10.4049/jimmunol.167.2.741",
      "volume": "167",
      "year": "2001",
      "journal-title": "J. Immunol."
    },
    {
      "key": "2023072512024898000_BIB27",
      "doi-asserted-by": "crossref",
      "first-page": "297",
      "DOI": "10.1146/annurev.immunol.15.1.297",
      "volume": "15",
      "year": "1997",
      "journal-title": "Annu. Rev. Immunol."
    },
    {
      "key": "2023072512024898000_BIB28",
      "doi-asserted-by": "crossref",
      "first-page": "116",
      "DOI": "10.1038/nri727",
      "volume": "2",
      "year": "2002",
      "journal-title": "Nat. Rev. Immunol."
    },
    {
      "key": "2023072512024898000_BIB29",
      "doi-asserted-by": "crossref",
      "first-page": "97",
      "DOI": "10.4049/jimmunol.154.1.97",
      "volume": "154",
      "year": "1995",
      "journal-title": "J. Immunol."
    },
    {
      "key": "2023072512024898000_BIB30",
      "doi-asserted-by": "crossref",
      "first-page": "707",
      "DOI": "10.1016/0092-8674(95)90349-6",
      "volume": "80",
      "year": "1995",
      "journal-title": "Cell."
    },
    {
      "key": "2023072512024898000_BIB31",
      "doi-asserted-by": "crossref",
      "first-page": "169",
      "DOI": "10.1016/S1074-7613(02)00273-X",
      "volume": "16",
      "year": "2002",
      "journal-title": "Immunity."
    },
    {
      "key": "2023072512024898000_BIB32",
      "doi-asserted-by": "crossref",
      "first-page": "153",
      "DOI": "10.1084/jem.20021109",
      "volume": "197",
      "year": "2003",
      "journal-title": "J. Exp. Med."
    },
    {
      "key": "2023072512024898000_BIB33",
      "doi-asserted-by": "crossref",
      "first-page": "495",
      "DOI": "10.1016/S1074-7613(01)00136-4",
      "volume": "14",
      "year": "2001",
      "journal-title": "Immunity."
    },
    {
      "key": "2023072512024898000_BIB34",
      "doi-asserted-by": "crossref",
      "first-page": "447",
      "DOI": "10.1084/jem.179.2.447",
      "volume": "179",
      "year": "1994",
      "journal-title": "J. Exp. Med."
    },
    {
      "key": "2023072512024898000_BIB35",
      "doi-asserted-by": "crossref",
      "first-page": "2066",
      "DOI": "10.1002/(SICI)1521-4141(199807)28:07<2066::AID-IMMU2066>3.0.CO;2-X",
      "volume": "28",
      "year": "1998",
      "journal-title": "Eur. J. Immunol."
    },
    {
      "key": "2023072512024898000_BIB36",
      "doi-asserted-by": "crossref",
      "first-page": "2289",
      "DOI": "10.1084/jem.188.12.2289",
      "volume": "188",
      "year": "1998",
      "journal-title": "J. Exp. Med."
    },
    {
      "key": "2023072512024898000_BIB37",
      "doi-asserted-by": "crossref",
      "first-page": "984",
      "DOI": "10.1126/science.271.5251.984",
      "volume": "271",
      "year": "1996",
      "journal-title": "Science."
    },
    {
      "key": "2023072512024898000_BIB38",
      "doi-asserted-by": "crossref",
      "first-page": "79",
      "DOI": "10.1016/S1286-4579(99)80018-5",
      "volume": "1",
      "year": "1999",
      "journal-title": "Microbes Infect."
    }
  ],
  "container-title": "The Journal of Experimental Medicine",
  "original-title": [],
  "language": "en",
  "link": [
    {
      "URL": "https://rupress.org/jem/article-pdf/198/2/201/1710336/jem1982201.pdf",
      "content-type": "application/pdf",
      "content-version": "vor",
      "intended-application": "syndication"
    },
    {
      "URL": "https://rupress.org/jem/article-pdf/198/2/201/1710336/jem1982201.pdf",
      "content-type": "unspecified",
      "content-version": "vor",
      "intended-application": "similarity-checking"
    }
  ],
  "deposited": {
    "date-parts": [
      [
        2023,
        7,
        25
      ]
    ],
    "date-time": "2023-07-25T12:08:57Z",
    "timestamp": 1690286937000
  },
  "score": 1,
  "resource": {
    "primary": {
      "URL": "https://rupress.org/jem/article/198/2/201/8462/CD4-T-Cell-Polarization-in-Mice-Is-Modulated-by"
    }
  },
  "subtitle": [],
  "short-title": [],
  "issued": {
    "date-parts": [
      [
        2003,
        7,
        14
      ]
    ]
  },
  "references-count": 38,
  "journal-issue": {
    "issue": "2",
    "published-print": {
      "date-parts": [
        [
          2003,
          7,
          21
        ]
      ]
    }
  },
  "URL": "http://dx.doi.org/10.1084/jem.20021893",
  "relation": {
    "has-review": [
      {
        "id-type": "doi",
        "id": "10.3410/f.1014543.193823",
        "asserted-by": "object"
      }
    ]
  },
  "ISSN": [
    "1540-9538",
    "0022-1007"
  ],
  "subject": [],
  "published": {
    "date-parts": [
      [
        2003,
        7,
        14
      ]
    ]
  }
}