DOI: 10.1084/jem.20020063. Suppression of Lymphoma and Epithelial Malignancies Effected by Interferon γ

Suppression of Lymphoma and Epithelial Malignancies Effected by Interferon γ

10.1084/jem.20020063

Crossref journal-article

Rockefeller University Press

The Journal of Experimental Medicine (291)

Abstract

The immunosurveillance of transformed cells by the immune system remains one of the most controversial and poorly understood areas of immunity. Gene-targeted mice have greatly aided our understanding of the key effector molecules in tumor immunity. Herein, we describe spontaneous tumor development in gene-targeted mice lacking interferon (IFN)-γ and/or perforin (pfp), or the immunoregulatory cytokines, interleukin (IL)-12, IL-18, and tumor necrosis factor (TNF). Both IFN-γ and pfp were critical for suppression of lymphomagenesis, however the level of protection afforded by IFN-γ was strain specific. Lymphomas arising in IFN-γ-deficient mice were very nonimmunogenic compared with those derived from pfp-deficient mice, suggesting a comparatively weaker immunoselection pressure by IFN-γ. Single loss of IL-12, IL-18, or TNF was not sufficient for spontaneous tumor development. A significant incidence of late onset adenocarcinoma observed in both IFN-γ– and pfp-deficient mice indicated that some epithelial tissues were also subject to immunosurveillance.

Bibliography

Street, S. E. A., Trapani, J. A., MacGregor, D., & Smyth, M. J. (2002). Suppression of Lymphoma and Epithelial Malignancies Effected by Interferon Î³. The Journal of Experimental Medicine, 196(1), 129â134.

Authors 4

Shayna E.A. Street (first)
Joseph A. Trapani (additional)
Duncan MacGregor (additional)
Mark J. Smyth (additional)

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Dates

Type	When
Created	23 years, 1 month ago (July 28, 2002, 6:32 p.m.)
Deposited	2 years, 1 month ago (July 25, 2023, 7:36 a.m.)
Indexed	5 days, 2 hours ago (Aug. 23, 2025, 9:10 p.m.)
Issued	23 years, 1 month ago (July 1, 2002)
Published	23 years, 1 month ago (July 1, 2002)
Published Online	23 years, 1 month ago (July 1, 2002)
Published Print	23 years, 1 month ago (July 1, 2002)

Funders 0

None

BibTeX

@article{Street_2002, title={Suppression of Lymphoma and Epithelial Malignancies Effected by Interferon γ}, volume={196}, ISSN={0022-1007}, url={http://dx.doi.org/10.1084/jem.20020063}, DOI={10.1084/jem.20020063}, number={1}, journal={The Journal of Experimental Medicine}, publisher={Rockefeller University Press}, author={Street, Shayna E.A. and Trapani, Joseph A. and MacGregor, Duncan and Smyth, Mark J.}, year={2002}, month=jul, pages={129–134} }

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