DOI: 10.1084/jem.20011171. Critical Role for Tumor Necrosis Factor–related Apoptosis-inducing Ligand in Immune Surveillance Against Tumor Development

Critical Role for Tumor Necrosis Factor–related Apoptosis-inducing Ligand in Immune Surveillance Against Tumor Development

10.1084/jem.20011171

Crossref journal-article

Rockefeller University Press

The Journal of Experimental Medicine (291)

Abstract

Natural killer (NK) cells and interferon (IFN)-γ have been implicated in immune surveillance against tumor development. Here we show that tumor necrosis factor–related apoptosis-inducing ligand (TRAIL) plays a critical role in the NK cell–mediated and IFN-γ–dependent tumor surveillance. Administration of neutralizing monoclonal antibody against TRAIL promoted tumor development in mice subcutaneously inoculated with a chemical carcinogen methylcholanthrene (MCA). This protective effect of TRAIL was at least partly mediated by NK cells and totally dependent on IFN-γ. In the absence of TRAIL, NK cells, or IFN-γ, TRAIL-sensitive sarcomas preferentially emerged in MCA-inoculated mice. Moreover, development of spontaneous tumors in p53+/− mice was also promoted by neutralization of TRAIL. These results indicated a substantial role of TRAIL as an effector molecule that eliminates developing tumors.

Bibliography

Takeda, K., Smyth, M. J., Cretney, E., Hayakawa, Y., Kayagaki, N., Yagita, H., & Okumura, K. (2002). Critical Role for Tumor Necrosis Factorârelated Apoptosis-inducing Ligand in Immune Surveillance Against Tumor Development. The Journal of Experimental Medicine, 195(2), 161â169.

Authors 7

Kazuyoshi Takeda (first)
Mark J. Smyth (additional)
Erika Cretney (additional)
Yoshihiro Hayakawa (additional)
Nobuhiko Kayagaki (additional)
Hideo Yagita (additional)
Ko Okumura (additional)

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Dates

Type	When
Created	23 years, 1 month ago (July 26, 2002, 12:48 p.m.)
Deposited	2 years, 1 month ago (July 25, 2023, 7:28 a.m.)
Indexed	2 weeks, 6 days ago (Aug. 7, 2025, 4:57 p.m.)
Issued	23 years, 7 months ago (Jan. 14, 2002)
Published	23 years, 7 months ago (Jan. 14, 2002)
Published Online	23 years, 7 months ago (Jan. 14, 2002)
Published Print	23 years, 7 months ago (Jan. 21, 2002)

Funders 0

None

BibTeX

@article{Takeda_2002, title={Critical Role for Tumor Necrosis Factor–related Apoptosis-inducing Ligand in Immune Surveillance Against Tumor Development}, volume={195}, ISSN={0022-1007}, url={http://dx.doi.org/10.1084/jem.20011171}, DOI={10.1084/jem.20011171}, number={2}, journal={The Journal of Experimental Medicine}, publisher={Rockefeller University Press}, author={Takeda, Kazuyoshi and Smyth, Mark J. and Cretney, Erika and Hayakawa, Yoshihiro and Kayagaki, Nobuhiko and Yagita, Hideo and Okumura, Ko}, year={2002}, month=jan, pages={161–169} }

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