A Critical Role for Interleukin 18 in Primary and Memory Effector Responses to Listeria monocytogenes That Extends Beyond Its Effects on Interferon γ Production
10.1084/jem.194.3.343
Crossref journal-article
Rockefeller University Press
The Journal of Experimental Medicine (291)
Abstract

The stimulation of interferon (IFN)-γ by interleukin (IL)-12 has been shown to provide protection from intracellular pathogens such as Listeria monocytogenes. Tumor necrosis factor (TNF) is also a major player in the resolution of Listeria infections and is suggested to have more global effects than can be explained by the induction of IFN-γ alone. Since IL-18 synergizes with IL-12 to induce IFN-γ production by natural killer and T helper (Th)1 cells, we determined its role in responses to Listeria. IL-18 appeared to be even more potent than either IL-12 or IFN-γ for protection against this pathogen and IL-18 enhanced bacterial clearance in the complete absence of IFN-γ. Indeed IL-18 was comparable to TNF in its ability to resolve the infection and showed a lowered protective capacity in the absence of TNF. Moreover, IL-18 induced macrophages to secrete both TNF and nitric oxide after a Listeria infection. IL-18 was also essential for optimal IFN-γ production by antigen-specific T cells. Therefore, IL-18 operates via its effects on both the innate immune response, including macrophages, as well as on Th1 cells, to protect against Listeria.

Bibliography

Neighbors, M., Xu, X., Barrat, F. J., Ruuls, S. R., Churakova, T., Debets, R., Bazan, J. F., Kastelein, R. A., Abrams, J. S., & O’Garra, A. (2001). A Critical Role for Interleukin 18 in Primary and Memory Effector Responses to Listeria monocytogenes That Extends Beyond Its Effects on Interferon γ Production. The Journal of Experimental Medicine, 194(3), 343–354.

Authors 10
  1. Margaret Neighbors (first)
  2. Xiuling Xu (additional)
  3. Franck J. Barrat (additional)
  4. Sigrid R. Ruuls (additional)
  5. Tatyana Churakova (additional)
  6. Reno Debets (additional)
  7. J. Fernando Bazan (additional)
  8. Robert A. Kastelein (additional)
  9. John S. Abrams (additional)
  10. Anne O'Garra (additional)
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Dates
Type When
Created 23 years, 1 month ago (July 26, 2002, 12:48 p.m.)
Deposited 2 years, 1 month ago (July 25, 2023, 7 a.m.)
Indexed 1 month, 3 weeks ago (July 4, 2025, 12:14 a.m.)
Issued 24 years ago (Aug. 6, 2001)
Published 24 years ago (Aug. 6, 2001)
Published Online 24 years ago (Aug. 6, 2001)
Published Print 24 years ago (Aug. 6, 2001)
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@article{Neighbors_2001, title={A Critical Role for Interleukin 18 in Primary and Memory Effector Responses to Listeria monocytogenes That Extends Beyond Its Effects on Interferon γ Production}, volume={194}, ISSN={1540-9538}, url={http://dx.doi.org/10.1084/jem.194.3.343}, DOI={10.1084/jem.194.3.343}, number={3}, journal={The Journal of Experimental Medicine}, publisher={Rockefeller University Press}, author={Neighbors, Margaret and Xu, Xiuling and Barrat, Franck J. and Ruuls, Sigrid R. and Churakova, Tatyana and Debets, Reno and Bazan, J. Fernando and Kastelein, Robert A. and Abrams, John S. and O’Garra, Anne}, year={2001}, month=aug, pages={343–354} }