DOI: 10.1084/jem.193.12.1403. Antibodies against Merozoite Surface Protein (Msp)-119 Are a Major Component of the Invasion-Inhibitory Response in Individuals Immune to Malaria

Antibodies against Merozoite Surface Protein (Msp)-119 Are a Major Component of the Invasion-Inhibitory Response in Individuals Immune to Malaria

10.1084/jem.193.12.1403

Crossref journal-article

Rockefeller University Press

The Journal of Experimental Medicine (291)

Abstract

Antibodies that bind to antigens expressed on the merozoite form of the malaria parasite can inhibit parasite growth by preventing merozoite invasion of red blood cells. Inhibitory antibodies are found in the sera of malaria-immune individuals, however, the specificity of those that are important to this process is not known. In this paper, we have used allelic replacement to construct a Plasmodium falciparum parasite line that expresses the complete COOH-terminal fragment of merozoite surface protein (MSP)-119 from the divergent rodent malaria P. chabaudi. By comparing this transfected line with parental parasites that differ only in MSP-119, we show that antibodies specific for this domain are a major component of the inhibitory response in P. falciparum–immune humans and P. chabaudi–immune mice. In some individual human sera, MSP-119 antibodies dominated the inhibitory activity. The finding that antibodies to a small region of a single protein play a major role in this process has important implications for malaria immunity and is strongly supportive of further understanding and development of MSP-119–based vaccines.

Bibliography

OâDonnell, R. A., de Koning-Ward, T. F., Burt, R. A., Bockarie, M., Reeder, J. C., Cowman, A. F., & Crabb, B. S. (2001). Antibodies against Merozoite Surface Protein (Msp)-119 Are a Major Component of the Invasion-Inhibitory Response in Individuals Immune to Malaria. The Journal of Experimental Medicine, 193(12), 1403â1412.

Authors 7

Rebecca A. O'Donnell (first)
Tania F. de Koning-Ward (additional)
Rachel A. Burt (additional)
Moses Bockarie (additional)
John C. Reeder (additional)
Alan F. Cowman (additional)
Brendan S. Crabb (additional)

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Dates

Type	When
Created	23 years, 1 month ago (July 26, 2002, 12:48 p.m.)
Deposited	2 years, 1 month ago (July 25, 2023, 6:46 a.m.)
Indexed	2 months ago (July 1, 2025, 8:06 a.m.)
Issued	24 years, 2 months ago (June 18, 2001)
Published	24 years, 2 months ago (June 18, 2001)
Published Online	24 years, 2 months ago (June 18, 2001)
Published Print	24 years, 2 months ago (June 18, 2001)

Funders 0

None

BibTeX

@article{O_Donnell_2001, title={Antibodies against Merozoite Surface Protein (Msp)-119 Are a Major Component of the Invasion-Inhibitory Response in Individuals Immune to Malaria}, volume={193}, ISSN={1540-9538}, url={http://dx.doi.org/10.1084/jem.193.12.1403}, DOI={10.1084/jem.193.12.1403}, number={12}, journal={The Journal of Experimental Medicine}, publisher={Rockefeller University Press}, author={O’Donnell, Rebecca A. and de Koning-Ward, Tania F. and Burt, Rachel A. and Bockarie, Moses and Reeder, John C. and Cowman, Alan F. and Crabb, Brendan S.}, year={2001}, month=jun, pages={1403–1412} }

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