DOI: 10.1084/jem.192.12.1755. Phosphorylated Peptides Are Naturally Processed and Presented by Major Histocompatibility Complex Class I Molecules in Vivo

Phosphorylated Peptides Are Naturally Processed and Presented by Major Histocompatibility Complex Class I Molecules in Vivo

10.1084/jem.192.12.1755

Crossref journal-article

Rockefeller University Press

The Journal of Experimental Medicine (291)

Abstract

Posttranslational modification of peptide antigens has been shown to alter the ability of T cells to recognize major histocompatibility complex (MHC) class I–restricted peptides. However, the existence and origin of naturally processed phosphorylated peptides presented by MHC class I molecules have not been explored. By using mass spectrometry, significant numbers of naturally processed phosphorylated peptides were detected in association with several human MHC class I molecules. In addition, CD8+ T cells could be generated that specifically recognized a phosphorylated epitope. Thus, phosphorylated peptides are part of the repertoire of antigens available for recognition by T cells in vivo.

Bibliography

Zarling, A. L., Ficarro, S. B., White, F. M., Shabanowitz, J., Hunt, D. F., & Engelhard, V. H. (2000). Phosphorylated Peptides Are Naturally Processed and Presented by Major Histocompatibility Complex Class I Molecules in Vivo. The Journal of Experimental Medicine, 192(12), 1755â1762.

Authors 6

Angela L. Zarling (first)
Scott B. Ficarro (additional)
Forest M. White (additional)
Jeffrey Shabanowitz (additional)
Donald F. Hunt (additional)
Victor H. Engelhard (additional)

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Dates

Type	When
Created	23 years, 1 month ago (July 26, 2002, 12:48 p.m.)
Deposited	2 years, 1 month ago (July 25, 2023, 6:32 a.m.)
Indexed	1 week, 6 days ago (Aug. 19, 2025, 6:44 a.m.)
Issued	24 years, 8 months ago (Dec. 18, 2000)
Published	24 years, 8 months ago (Dec. 18, 2000)
Published Online	24 years, 8 months ago (Dec. 18, 2000)
Published Print	24 years, 8 months ago (Dec. 18, 2000)

Funders 0

None

BibTeX

@article{Zarling_2000, title={Phosphorylated Peptides Are Naturally Processed and Presented by Major Histocompatibility Complex Class I Molecules in Vivo}, volume={192}, ISSN={1540-9538}, url={http://dx.doi.org/10.1084/jem.192.12.1755}, DOI={10.1084/jem.192.12.1755}, number={12}, journal={The Journal of Experimental Medicine}, publisher={Rockefeller University Press}, author={Zarling, Angela L. and Ficarro, Scott B. and White, Forest M. and Shabanowitz, Jeffrey and Hunt, Donald F. and Engelhard, Victor H.}, year={2000}, month=dec, pages={1755–1762} }

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