DOI: 10.1084/jem.191.3.573. A Broad Spectrum Secreted Chemokine Binding Protein Encoded by a Herpesvirus

A Broad Spectrum Secreted Chemokine Binding Protein Encoded by a Herpesvirus

10.1084/jem.191.3.573

Crossref journal-article

Rockefeller University Press

The Journal of Experimental Medicine (291)

Abstract

Chemokines are a family of small proteins that interact with seven-transmembrane domain receptors and modulate the migration of immune cells into sites of inflammation and infection. The murine gammaherpesvirus 68 M3 gene encodes a secreted 44-kD protein with no sequence similarity to known chemokine receptors. We show that M3 binds a broad range of chemokines, including CC, CXC, C, and CX3C chemokines, but does not bind human B cell–specific nor mouse neutrophil–specific CXC chemokines. This herpesvirus chemokine binding protein (hvCKBP) blocks the interaction of chemokines with high-affinity cellular receptors and inhibits chemokine-induced elevation of intracellular calcium levels. hvCKBP is the first soluble chemokine receptor identified in herpesviruses; it represents a novel protein structure with the ability to bind all subfamilies of chemokines in solution and has potential therapeutic applications.

Bibliography

Parry, C. M., Simas, J. P., Smith, V. P., Stewart, C. A., Minson, A. C., Efstathiou, S., & Alcami, A. (2000). A Broad Spectrum Secreted Chemokine Binding Protein Encoded by a Herpesvirus. The Journal of Experimental Medicine, 191(3), 573â578.

Authors 7

Christopher M. Parry (first)
J. Pedro Simas (additional)
Vincent P. Smith (additional)
C. Andrew Stewart (additional)
Anthony C. Minson (additional)
Stacey Efstathiou (additional)
Antonio Alcami (additional)

References 29 Referenced 187

10.1038/33340 / Nature. / Chemokines and leukocyte traffic by Baggiolini (1998)
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10.1111/j.1600-065X.1997.tb01012.x / Immunol. Rev. / Vaccinia virus immune evasion by Smith (1997)
10.1006/smvy.1997.0143 / Semin. Virol. / Poxvirusescapturing cytokines and chemokines by Alcami (1998)
10.1006/smvy.1997.0146 / Semin. Virol. / Abduction of chemokine elements by herpesviruses by Dairaghi (1998)
{'key': '2023072509003490200_R8', 'first-page': '468', 'article-title': 'Isolation of five strains of herpesviruses from two species of free living small rodents', 'volume': '24', 'author': 'Blaskovic', 'year': '1980', 'journal-title': 'Acta Virol.'} / Acta Virol. / Isolation of five strains of herpesviruses from two species of free living small rodents by Blaskovic (1980)
10.1099/0022-1317-71-6-1365 / J. Gen. Virol. / Murine herpesvirus 68 is genetically related to the gammaherpesviruses Epstein-Barr virus and herpesvirus saimiri by Efstathiou (1990)
10.1128/jvi.71.8.5894-5904.1997 / J. Virol. / Complete sequence and genomic analysis of murine gammaherpesvirus 68 by Virgin (1997)
10.1016/S0966-842X(98)01306-7 / Trends Microbiol. / Murine gammaherpesvirus 68a model for the study of gammaherpesvirus pathogenesis by Simas (1998)
10.1016/S0952-7915(97)80098-2 / Curr. Opin. Immunol. / Tuning into immunological dissonancean experimental model for infectious mononucleosis by Doherty (1997)
10.1099/0022-1317-73-12-3275 / J. Gen. Virol. / Murine gammaherpesvirus 68 establishes a latent infection in mouse B lymphocytes in vivo by Sunil-Chandra (1992)
10.1099/0022-1317-77-11-2819 / J. Gen. Virol. / Absence of splenic latency in murine gammaherpesvirus 68-infected B cell-deficient mice by Usherwood (1996)
10.1128/JVI.73.6.4651-4661.1999 / J. Virol. / B cells regulate murine gammaherpesvirus 68 latency by Weck (1999)
10.1128/JVI.73.4.3273-3283.1999 / J. Virol. / Macrophages are the major reservoir of latent murine gammaherpesvirus 68 in peritoneal cells by Weck (1999)
10.1099/0022-1317-80-1-75 / J. Gen. Virol. / Analysis of murine gammaherpesvirus-68 transcription during lytic and latent infection by Simas (1999)
10.1128/JVI.73.5.4524-4529.1999 / J. Virol. / Identification and initial characterization of the murine gammaherpesvirus 68 gene M3, encoding an abundantly secreted protein by van Berkel (1999)
10.1099/0022-1317-79-1-149 / J. Gen. Virol. / Four tRNA-like sequences and a serpin homologue encoded by murine gammaherpesvirus 68 are dispensable for lytic replication in vitro and latency in vivo by Simas (1998)
10.1093/nar/20.9.2233 / Nucleic Acids Res. / Constitutive and enhanced expression from the CMV major IE promoter in a defective adenovirus vector by Wilkinson (1992)
10.4049/jimmunol.160.2.624 / J. Immunol. / Blockade of chemokine activity by a soluble chemokine binding protein from vaccinia virus by Alcami (1998)
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10.1099/0022-1317-78-7-1675 / J. Gen. Virol. / Murine gammaherpesvirus 68 encodes tRNA-like sequences which are expressed during latency by Bowden (1997)
10.1128/JVI.73.3.2321-2332.1999 / J. Virol. / Three distinct regions of the murine gammaherpesvirus 68 genome are transcriptionally active in latently infected mice by Virgin (1999)
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10.1084/jem.187.4.655 / J. Exp. Med. / B cell–attracting chemokine 1, a human CXC chemokine expressed in lymphoid tissues, selectively attracts B lymphocytes via BLR1/CXCR5 by Legler (1998)
10.1126/science.278.5336.290 / Science. / Angiogenic and HIV-inhibitory functions of KSHV-encoded chemokines by Boshoff (1997)

Dates

Type	When
Created	23 years, 1 month ago (July 26, 2002, 12:48 p.m.)
Deposited	2 years, 1 month ago (July 25, 2023, 6:11 a.m.)
Indexed	4 months, 3 weeks ago (April 11, 2025, 4:48 a.m.)
Issued	25 years, 6 months ago (Feb. 7, 2000)
Published	25 years, 6 months ago (Feb. 7, 2000)
Published Online	25 years, 6 months ago (Feb. 7, 2000)
Published Print	25 years, 6 months ago (Feb. 7, 2000)

Funders 0

None

BibTeX

@article{Parry_2000, title={A Broad Spectrum Secreted Chemokine Binding Protein Encoded by a Herpesvirus}, volume={191}, ISSN={1540-9538}, url={http://dx.doi.org/10.1084/jem.191.3.573}, DOI={10.1084/jem.191.3.573}, number={3}, journal={The Journal of Experimental Medicine}, publisher={Rockefeller University Press}, author={Parry, Christopher M. and Simas, J. Pedro and Smith, Vincent P. and Stewart, C. Andrew and Minson, Anthony C. and Efstathiou, Stacey and Alcami, Antonio}, year={2000}, month=feb, pages={573–578} }

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        7
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  "URL": "http://dx.doi.org/10.1084/jem.191.3.573",
  "relation": {},
  "ISSN": [
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    "1540-9538"
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  "subject": [],
  "published": {
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        2,
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}