DOI: 10.1084/jem.190.8.1155. Human Dendritic Cells Mediate Cellular Apoptosis via Tumor Necrosis Factor–Related Apoptosis-Inducing Ligand (Trail)

Human Dendritic Cells Mediate Cellular Apoptosis via Tumor Necrosis Factor–Related Apoptosis-Inducing Ligand (Trail)

10.1084/jem.190.8.1155

Crossref journal-article

Rockefeller University Press

The Journal of Experimental Medicine (291)

Abstract

TRAIL (TNF-related apoptosis-inducing ligand) is a member of the TNF family that induces apoptosis in a variety of cancer cells. In this study, we demonstrate that human CD11c+ blood dendritic cells (DCs) express TRAIL after stimulation with either interferon (IFN)-γ or -α and acquire the ability to kill TRAIL-sensitive tumor cell targets but not TRAIL-resistant tumor cells or normal cell types. The DC-mediated apoptosis was TRAIL specific, as soluble TRAIL receptor blocked target cell death. Moreover, IFN-stimulated interleukin (IL)-3 receptor (R)α+ blood precursor (pre-)DCs displayed minimal cytotoxicity toward the same target cells, demonstrating a clear functional difference between the CD11c+ DC and IL-3Rα+ pre-DC subsets. These results indicate that TRAIL may serve as an innate effector molecule on CD11c+ DCs for the elimination of spontaneously arising tumor cells and suggest a means by which TRAIL-expressing DCs may regulate or eliminate T cells responding to antigen presented by the DCs.

Bibliography

Fanger, N. A., Maliszewski, C. R., Schooley, K., & Griffith, T. S. (1999). Human Dendritic Cells Mediate Cellular Apoptosis via Tumor Necrosis FactorâRelated Apoptosis-Inducing Ligand (Trail). The Journal of Experimental Medicine, 190(8), 1155â1164.

Authors 4

Neil A. Fanger (first)
Charles R. Maliszewski (additional)
Ken Schooley (additional)
Thomas S. Griffith (additional)

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Dates

Type	When
Created	23 years, 1 month ago (July 26, 2002, 12:48 p.m.)
Deposited	2 years, 1 month ago (July 25, 2023, 6:04 a.m.)
Indexed	2 days, 20 hours ago (Aug. 29, 2025, 6:14 a.m.)
Issued	25 years, 10 months ago (Oct. 18, 1999)
Published	25 years, 10 months ago (Oct. 18, 1999)
Published Online	25 years, 10 months ago (Oct. 18, 1999)
Published Print	25 years, 10 months ago (Oct. 18, 1999)

Funders 0

None

BibTeX

@article{Fanger_1999, title={Human Dendritic Cells Mediate Cellular Apoptosis via Tumor Necrosis Factor–Related Apoptosis-Inducing Ligand (Trail)}, volume={190}, ISSN={1540-9538}, url={http://dx.doi.org/10.1084/jem.190.8.1155}, DOI={10.1084/jem.190.8.1155}, number={8}, journal={The Journal of Experimental Medicine}, publisher={Rockefeller University Press}, author={Fanger, Neil A. and Maliszewski, Charles R. and Schooley, Ken and Griffith, Thomas S.}, year={1999}, month=oct, pages={1155–1164} }

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