In Vivo Expression of Natural Killer Cell Inhibitory Receptors by Human Melanoma–Specific Cytolytic T Lymphocytes
10.1084/jem.190.6.775
Crossref journal-article
Rockefeller University Press
The Journal of Experimental Medicine (291)
Abstract

Natural killer (NK) receptor signaling can lead to reduced cytotoxicity by NK cells and cytolytic T lymphocytes (CTLs) in vitro. Whether T cells are inhibited in vivo remains unknown, since peptide antigen–specific CD8+ T cells have so far not been found to express NK receptors in vivo. Here we demonstrate that melanoma patients may bear tumor-specific CTLs expressing NK receptors. The lysis of melanoma cells by patient-derived CTLs was inhibited by the NK receptor CD94/NKG2A. Thus, tumor-specific CTL activity may be decreased through NK receptor triggering in vivo.

Bibliography

Speiser, D. E., Pittet, M. J., Valmori, D., Dunbar, R., Rimoldi, D., Liénard, D., MacDonald, H. R., Cerottini, J.-C., Cerundolo, V., & Romero, P. (1999). In Vivo Expression of Natural Killer Cell Inhibitory Receptors by Human Melanoma–Specific Cytolytic T Lymphocytes. The Journal of Experimental Medicine, 190(6), 775–782.

Authors 10
  1. Daniel E. Speiser (first)
  2. Mikaël J. Pittet (additional)
  3. Danila Valmori (additional)
  4. Rod Dunbar (additional)
  5. Donata Rimoldi (additional)
  6. Danielle Liénard (additional)
  7. H. Robson MacDonald (additional)
  8. Jean-Charles Cerottini (additional)
  9. Vincenzo Cerundolo (additional)
  10. Pedro Romero (additional)
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Dates
Type When
Created 23 years, 1 month ago (July 26, 2002, 12:48 p.m.)
Deposited 2 years, 1 month ago (July 25, 2023, 6:01 a.m.)
Indexed 1 month ago (July 24, 2025, 8:19 a.m.)
Issued 25 years, 11 months ago (Sept. 20, 1999)
Published 25 years, 11 months ago (Sept. 20, 1999)
Published Online 25 years, 11 months ago (Sept. 20, 1999)
Published Print 25 years, 11 months ago (Sept. 20, 1999)
Funders 0

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@article{Speiser_1999, title={In Vivo Expression of Natural Killer Cell Inhibitory Receptors by Human Melanoma–Specific Cytolytic T Lymphocytes}, volume={190}, ISSN={1540-9538}, url={http://dx.doi.org/10.1084/jem.190.6.775}, DOI={10.1084/jem.190.6.775}, number={6}, journal={The Journal of Experimental Medicine}, publisher={Rockefeller University Press}, author={Speiser, Daniel E. and Pittet, Mikaël J. and Valmori, Danila and Dunbar, Rod and Rimoldi, Donata and Liénard, Danielle and MacDonald, H. Robson and Cerottini, Jean-Charles and Cerundolo, Vincenzo and Romero, Pedro}, year={1999}, month=sep, pages={775–782} }