DOI: 10.1084/jem.189.8.1285. A Critical Role for Fas Ligand in the Active Suppression of Systemic Immune Responses by Ultraviolet Radiation

A Critical Role for Fas Ligand in the Active Suppression of Systemic Immune Responses by Ultraviolet Radiation

10.1084/jem.189.8.1285

Crossref journal-article

Rockefeller University Press

The Journal of Experimental Medicine (291)

Abstract

Induction of antigen-specific suppression elicited by environmental insults, such as ultraviolet (UV)-B radiation in sunlight, can inhibit an effective immune response in vivo and may contribute to the outgrowth of UV-induced skin cancer. Although UV-induced DNA damage is known to be an initiating event in the immune suppression of most antigen responses, the underlying mechanism(s) of such suppression remain undefined. In this report, we document that Fas ligand (FasL) is critical for UV-induced systemic immune suppression. Normal mice acutely exposed to UV exhibit a profound suppression of both contact hypersensitivity and delayed type hypersensitivity (DTH) reactions and the development of transferable antigen-specific suppressor cells. FasL-deficient mice exposed to UV lack both transferable suppressor cell activity and primary suppression to all antigens tested, with the exception of the DTH response to allogeneic spleen cells. Interestingly, suppression of this response is also known to occur independently of UV-induced DNA damage. Delivery of alloantigen as protein, rather than intact cells, restored the requirement for FasL in UV-induced immune suppression of this response. These results substantiate that FasL/Fas interactions are essential for systemic UV-induced suppression of immune responses that involve host antigen presentation and suggest an interrelationship between UV-induced DNA damage and FasL in this phenomenon. Collectively, our results suggest a model whereby UV-induced DNA damage disarms the immune system in a manner similar to that observed in immunologically privileged sites.

Bibliography

Hill, L. L., Shreedhar, V. K., Kripke, M. L., & Owen-Schaub, L. B. (1999). A Critical Role for Fas Ligand in the Active Suppression of Systemic Immune Responses by Ultraviolet Radiation. The Journal of Experimental Medicine, 189(8), 1285â1294.

Authors 4

Laurie L. Hill (first)
Vijay K. Shreedhar (additional)
Margaret L. Kripke (additional)
Laurie B. Owen-Schaub (additional)

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Dates

Type	When
Created	23 years, 1 month ago (July 26, 2002, 12:48 p.m.)
Deposited	2 years, 1 month ago (July 25, 2023, 5:50 a.m.)
Indexed	3 months, 1 week ago (May 18, 2025, 12:22 p.m.)
Issued	26 years, 4 months ago (April 19, 1999)
Published	26 years, 4 months ago (April 19, 1999)
Published Online	26 years, 4 months ago (April 19, 1999)
Published Print	26 years, 4 months ago (April 19, 1999)

Funders 0

None

BibTeX

@article{Hill_1999, title={A Critical Role for Fas Ligand in the Active Suppression of Systemic Immune Responses by Ultraviolet Radiation}, volume={189}, ISSN={1540-9538}, url={http://dx.doi.org/10.1084/jem.189.8.1285}, DOI={10.1084/jem.189.8.1285}, number={8}, journal={The Journal of Experimental Medicine}, publisher={Rockefeller University Press}, author={Hill, Laurie L. and Shreedhar, Vijay K. and Kripke, Margaret L. and Owen-Schaub, Laurie B.}, year={1999}, month=apr, pages={1285–1294} }

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