DOI: 10.1084/jem.189.10.1555. Noncytopathic Clearance of Lymphocytic Choriomeningitis Virus from the Hepatocyte

Noncytopathic Clearance of Lymphocytic Choriomeningitis Virus from the Hepatocyte

10.1084/jem.189.10.1555

Crossref journal-article

Rockefeller University Press

The Journal of Experimental Medicine (291)

Abstract

We have previously shown that interferon and tumor necrosis factor noncytopathically abolish hepatitis B virus (HBV) replication from the hepatocyte and kidney tubular epithelial cells in vivo. Here we show that a persistent lymphocytic choriomeningitis virus (LCMV) infection is cleared from the hepatocyte noncytopathically when the same cytokines are induced in the liver by antigen-nonspecific stimuli. These results indicate that, like HBV, LCMV is also susceptible to intracellular inactivation by cytokine-induced antiviral mechanisms that are operative in the hepatocyte. In contrast, LCMV is not cleared from intrahepatic nonparenchymal cells or splenocytes, indicating that, unlike the hepatocyte, these cells do not produce the factors required to inactivate LCMV. Antiviral mechanisms like these may have evolved to maintain the functional integrity of vital organs in the face of massive infection.

Bibliography

Guidotti, L. G., Borrow, P., Brown, A., McClary, H., Koch, R., & Chisari, F. V. (1999). Noncytopathic Clearance of Lymphocytic Choriomeningitis Virus from the Hepatocyte. The Journal of Experimental Medicine, 189(10), 1555â1564.

Authors 6

Luca G. Guidotti (first)
Persephone Borrow (additional)
Amy Brown (additional)
Heike McClary (additional)
Rick Koch (additional)
Francis V. Chisari (additional)

References 31 Referenced 123

10.1016/S1074-7613(00)80295-2 / Immunity / Intracellular inactivation of the hepatitis B virus by cytotoxic T lymphocytes by Guidotti (1996)
10.1128/jvi.71.4.3236-3243.1997 / J Virol / Interleukin-12 inhibits hepatitis B virus replication in HBV transgenic mice by Cavanaugh (1997)
10.1073/pnas.93.10.4589 / Proc Natl Acad Sci USA / Viral cross talk: intracellular inactivation of the hepatitis B virus during an unrelated viral infection of the liver by Guidotti (1996)
10.1128/JVI.72.4.2630-2637.1998 / J Virol / Inhibition of hepatitis B virus replication during adenovirus and cytomegalovirus infections in HBV transgenic mice by Cavanaugh (1998)
10.1126/science.284.5415.825 / Science / Viral clearance without destruction of infected cells during acute HBV infection by Guidotti (1999)
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10.1038/369031a0 / Nature / Cytotoxicity mediated by T cells and natural killer cells is greatly impaired in perforin-deficient mice by Kagi (1994)
10.1073/pnas.91.23.10854 / Proc Natl Acad Sci USA / Immune function in mice lacking the perforin gene by Walsh (1994)
10.1126/science.8009221 / Science / Functional role of type I and type II interferons in antiviral defense by Muller (1994)
10.1128/jvi.63.6.2813-2819.1989 / J Virol / Enhanced virus replication and inhibition of lymphocytic choriomeningitis virus disease in anti-gamma interferon-treated mice by Leist (1989)
10.1002/eji.1830190720 / Eur J Immunol / Mechanism of recovery from acute virus infection. VIII. Treatment of lymphocytic choriomeningitis virus- infected mice with anti-interferon-gamma monoclonal antibody blocks generation of virus-specific cytotoxic T lymphocytes and virus elimination by Wille (1989)
10.1128/jvi.68.3.1951-1955.1994 / J Virol / Resistance of lymphocytic choriomeningitis virus to alpha/beta interferon and gamma interferon by Moskophidis (1994)
10.4049/jimmunol.134.1.608 / J Immunol / Mechanism of recovery from acute virus infection. I. Role of T lymphocytes in the clearance of lymphocytic choriomeningitis virus from spleens of mice by Lehmann-Grube (1985)
10.4049/jimmunol.149.10.3331 / J Immunol / Control of acute infection with lymphocytic choriomeningitis virus in mice that cannot present an immunodominant viral cytotoxic T lymphocyte epitope by Gegin (1992)
10.1006/viro.1995.1477 / Virology / An essential role for type 1 interferon-γ in terminating persistent viral infection by Tishon (1995)
10.1099/0022-1317-64-8-1689 / J Gen Virol / Genomic and biological variation among commonly used lymphocytic choriomeningitis virus strains by Dutko (1983)
10.1016/0959-437X(93)90126-A / Curr Opin Genet Dev / Gene therapy: adenovirus vectors by Kozarsky (1993)
10.1099/0022-1317-36-1-59 / J Gen Virol / Characteristics of a human cell line transformed by DNA from human adenovirus type 5 by Graham (1977)
10.1038/ng0593-27 / Nat Genet / Direct gene transfer of human CFTR into human bronchial epithelia of xenografts with E1-deleted adenoviruses by Engelhardt (1993)
10.1016/0003-2697(87)90021-2 / Anal Biochem / Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction by Chomczynski (1987)
10.4049/jimmunol.150.8.3602 / J Immunol / Patterns of cytokine gene expression by CD4 T cells from young and old mice by Hobbs (1993)
10.1128/jvi.69.10.6158-6169.1995 / J Virol / High level hepatitis B virus replication in transgenic mice by Guidotti (1995)
10.1016/0042-6822(87)90323-0 / Virology / Molecular characterization of the genomic S RNA segment from lymphocytic choriomeningitis virus by Southern (1987)
10.1128/jvi.68.11.7367-7373.1994 / J Virol / Virus-induced immunosuppression: kinetic analysis of the selection of a mutation associated with viral persistence by Evans (1994)
10.1084/jem.176.2.495 / J Exp Med / Two subsets of epithelial cells in the thymic medulla by Surh (1992)
10.1016/0022-1759(84)90227-8 / J Immunol Methods / Immune lysis of hepatocytes in culture: accurate detection by aspartate aminotransferase release measurement by Feutren (1984)
10.1084/jem.178.5.1541 / J Exp Med / Mechanisms of class I–restricted immunopathology. A transgenic mouse model of fulminant hepatitis by Ando (1993)
10.1073/pnas.94.13.6874 / Proc Natl Acad Sci USA / A critical role for neutralizing-antibody-producing B cells, CD4+T cells, and interferons in persistent and acute infections of mice with lymphocytic choriomeningitis virus: implications for adoptive immunotherapy of virus carriers by Planz (1997)
10.1016/0167-5699(94)90137-6 / Immunol Today / The acute phase response by Baumann (1994)
10.1016/S0952-7915(96)80034-3 / Curr Opin Immunol / To kill or to cure: options in host defense against viral infection by Guidotti (1996)
10.1128/jvi.71.1.267-275.1997 / J Virol / Distinct organ-dependent mechanisms for the control of murine cytomegalovirus infection by natural killer cells by Tay (1997)

Dates

Type	When
Created	23 years ago (July 26, 2002, 12:49 p.m.)
Deposited	2 years, 1 month ago (July 25, 2023, 5:37 a.m.)
Indexed	2 months, 2 weeks ago (June 10, 2025, 3:28 a.m.)
Issued	26 years, 3 months ago (May 17, 1999)
Published	26 years, 3 months ago (May 17, 1999)
Published Online	26 years, 3 months ago (May 17, 1999)
Published Print	26 years, 3 months ago (May 17, 1999)

Funders 0

None

BibTeX

@article{Guidotti_1999, title={Noncytopathic Clearance of Lymphocytic Choriomeningitis Virus from the Hepatocyte}, volume={189}, ISSN={1540-9538}, url={http://dx.doi.org/10.1084/jem.189.10.1555}, DOI={10.1084/jem.189.10.1555}, number={10}, journal={The Journal of Experimental Medicine}, publisher={Rockefeller University Press}, author={Guidotti, Luca G. and Borrow, Persephone and Brown, Amy and McClary, Heike and Koch, Rick and Chisari, Francis V.}, year={1999}, month=may, pages={1555–1564} }

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