DOI: 10.1084/jem.187.4.537. An Interleukin (IL)-10/IL-12 Immunoregulatory Circuit Controls Susceptibility to Autoimmune Disease

An Interleukin (IL)-10/IL-12 Immunoregulatory Circuit Controls Susceptibility to Autoimmune Disease

10.1084/jem.187.4.537

Crossref journal-article

Rockefeller University Press

The Journal of Experimental Medicine (291)

Abstract

Cells of the innate immune system secrete cytokines early in immune responses that guide maturing T helper (Th) cells along appropriate lineages. This study investigates the role of cytokine networks, bridging the innate and acquired immune systems, in the pathogenesis of an organ specific autoimmune disease. Experimental allergic encephalomyelitis (EAE), a demyelinating disease of the central nervous system, is widely used as an animal model for multiple sclerosis. We demonstrate that interleukin (IL)-12 is essential for the generation of the autoreactive Th1 cells that induce EAE, both in the presence and absence of interferon γ. The disease-promoting effects of IL-12 are antagonized by IL-10 produced by an antigen nonspecific CD4+ T cell which, in turn, is regulated by the endogenous production of IL-12. This unique immunoregulatory circuit appears to play a critical role in controlling Th cell differentiation and provides a mechanism by which microbial triggers of the innate immune system can modulate autoimmune disease.

Bibliography

Segal, B. M., Dwyer, B. K., & Shevach, E. M. (1998). An Interleukin (IL)-10/IL-12 Immunoregulatory Circuit Controls Susceptibility to Autoimmune Disease. The Journal of Experimental Medicine, 187(4), 537â546.

Authors 3

Benjamin M. Segal (first)
Bonnie K. Dwyer (additional)
Ethan M. Shevach (additional)

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Dates

Type	When
Created	23 years, 1 month ago (July 26, 2002, 12:49 p.m.)
Deposited	2 years, 1 month ago (July 29, 2023, 11:32 a.m.)
Indexed	1 month ago (Aug. 2, 2025, 1:23 a.m.)
Issued	27 years, 6 months ago (Feb. 16, 1998)
Published	27 years, 6 months ago (Feb. 16, 1998)
Published Online	27 years, 6 months ago (Feb. 16, 1998)
Published Print	27 years, 6 months ago (Feb. 16, 1998)

Funders 0

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BibTeX

@article{Segal_1998, title={An Interleukin (IL)-10/IL-12 Immunoregulatory Circuit Controls Susceptibility to Autoimmune Disease}, volume={187}, ISSN={1540-9538}, url={http://dx.doi.org/10.1084/jem.187.4.537}, DOI={10.1084/jem.187.4.537}, number={4}, journal={The Journal of Experimental Medicine}, publisher={Rockefeller University Press}, author={Segal, Benjamin M. and Dwyer, Bonnie K. and Shevach, Ethan M.}, year={1998}, month=feb, pages={537–546} }

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