DOI: 10.1084/jem.187.3.433. Induction of an Antigen-specific, CD1-restricted Cytotoxic T Lymphocyte Response In vivo

Induction of an Antigen-specific, CD1-restricted Cytotoxic T Lymphocyte Response In vivo

10.1084/jem.187.3.433

Crossref journal-article

Rockefeller University Press

The Journal of Experimental Medicine (291)

Abstract

The majority of T cell responses are restricted to peptide antigens bound by polymorphic major histocompatibility complex (MHC) molecules. However, peptide antigens can be presented to T cells by murine non-MHC–encoded CD1d (mCD1) molecules, and human T cell lines specific for nonpeptide antigens presented on CD1 isoforms have been identified. It is shown here that antigen-specific, mCD1-restricted lymphocytes can be generated in vivo by immunizing mice with a combination of plasmids encoding chicken ovalbumin, murine CD1d, and costimulatory molecules. Splenocytes from immunized mice have CD1d-restricted, MHC- unrestricted, ovalbumin-specific cytolytic activity that can be inhibited by anti-CD1 antibodies as well as a competing CD1-binding peptide. These results suggest a physiologic role for murine CD1d to present exogenous protein antigens.

Bibliography

Lee, D. J., Abeyratne, A., Carson, D. A., & Corr, M. (1998). Induction of an Antigen-specific, CD1-restricted Cytotoxic T Lymphocyte Response In vivo. The Journal of Experimental Medicine, 187(3), 433â438.

Authors 4

Delphine J. Lee (first)
Amila Abeyratne (additional)
Dennis A. Carson (additional)
Maripat Corr (additional)

References 35 Referenced 41

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10.1126/science.7542403 / Science / Peptide binding and presentation by mouse CD1 by Castano (1995)
10.1073/pnas.83.23.9154 / Proc Natl Acad Sci USA / Isolation of CD1 genes: a family of major histocompatibility complex- related differentiation antigens by Martin (1986)
10.1007/BF02425277 / Immunogenetics / The rabbit CD1 and the evolutionary conservation of the CD1 gene family by Calabi (1989)
10.1002/eji.1830190211 / Eur J Immunol / Two classes of CD1 genes by Calabi (1989)
10.4049/jimmunol.146.2.768 / J Immunol / Isolation and expression of cDNA encoding the murine homologues of CD1 by Balk (1991)
10.1126/science.7517575 / Science / Beta 2-microglobulin-independent MHC class Ib molecule expressed by human intestinal epithelium by Balk (1994)
10.1016/0198-8859(94)90086-8 / Hum Immunol / CD1 expression is not affected by human peptide transporter deficiency by Hanau (1994)
10.1084/jem.182.6.1913 / J Exp Med / TAP-independent, β2-microglobulin-dependent surface expression of functional mouse CD1.1 by Brutkiewicz (1995)
10.4049/jimmunol.158.5.2143 / J Immunol / Nonclassical behavior of the mouse CD1 class I-like molecule by Teitell (1997)
10.1126/science.273.5273.349 / Science / Cytoplasmic tail-dependent localization of CD1b antigen-presenting molecules to MIICs by Sugita (1996)
10.1038/360593a0 / Nature / CD1b restricts the response of human CD4-8-T lymphocytes to a microbial antigen by Porcelli (1992)
10.1016/S1074-7613(00)80425-2 / Immunity / The mannose receptor delivers lipoglycan antigens to endosomes for presentation to T cells by CD1b molecules by Prigozy (1997)
10.1084/jem.182.2.325 / J Exp Med / Major histocompatibility complex class II compartments in human B lymphoblastoid cells are distinct from early endosomes by Peters (1995)
10.1038/349669a0 / Nature / Segregation of MHC class II molecules from MHC class I molecules in the Golgi complex for transport to lysosomal compartments by Peters (1991)
10.1038/369120a0 / Nature / Isolation and characterization of the intracellular MHC class II compartment [see comments] by Tulp (1994)
10.1126/science.7985027 / Science / Accumulation of HLA-DM, a regulator of antigen presentation, in MHC class II compartments by Sanderson (1994)
10.1038/372691a0 / Nature / Recognition of a lipid antigen by CD1-restricted alpha beta+T cells by Beckman (1994)
10.1126/science.7542404 / Science / CD1-restricted T cell recognition of microbial lipoglycan antigens by Sieling (1995)
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10.1126/science.7538697 / Science / CD1 recognition by mouse NK1+ T lymphocytes by Bendelac (1995)
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10.1073/pnas.91.20.9519 / Proc Natl Acad Sci USA / Intradermal gene immunization: the possible role of DNA uptake in the induction of cellular immunity to viruses by Raz (1994)
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10.1126/science.276.5319.1684 / Science / Differential effects of cytolytic T cell subsets on intracellular infection by Stenger (1997)
10.1126/science.277.5324.339 / Science / Crystal structure of mouse CD1: an MHC-like fold with a large hydrophobic binding groove by Zeng (1997)
10.1126/science.277.5324.332 / Science / Antigen presentation: a balanced diet by Brenner (1997)
10.1084/jem.179.4.1285 / J Exp Med / CD4pos, NK1.1pos T cells promptly produce interleukin 4 in response to in vivo challenge with anti-CD3 by Yoshimoto (1994)
10.1084/jem.184.1.131 / J Exp Med / A role for CD4+ NK1.1+T lymphocytes as major histocompatibility complex class II–independent helper cells in the generation of CD8+ effector function against intracellular infection by Denkers (1996)

Dates

Type	When
Created	23 years, 1 month ago (July 26, 2002, 12:48 p.m.)
Deposited	2 years, 1 month ago (July 25, 2023, 4:47 a.m.)
Indexed	2 months ago (June 27, 2025, 9:44 a.m.)
Issued	27 years, 6 months ago (Feb. 2, 1998)
Published	27 years, 6 months ago (Feb. 2, 1998)
Published Online	27 years, 6 months ago (Feb. 2, 1998)
Published Print	27 years, 6 months ago (Feb. 2, 1998)

Funders 0

None

BibTeX

@article{Lee_1998, title={Induction of an Antigen-specific, CD1-restricted Cytotoxic T Lymphocyte Response In vivo}, volume={187}, ISSN={1540-9538}, url={http://dx.doi.org/10.1084/jem.187.3.433}, DOI={10.1084/jem.187.3.433}, number={3}, journal={The Journal of Experimental Medicine}, publisher={Rockefeller University Press}, author={Lee, Delphine J. and Abeyratne, Amila and Carson, Dennis A. and Corr, Maripat}, year={1998}, month=feb, pages={433–438} }

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