DOI: 10.1084/jem.187.2.177. Interleukin 10 Secretion and Impaired Effector Function of Major Histocompatibility Complex Class II

Interleukin 10 Secretion and Impaired Effector Function of Major Histocompatibility Complex Class II–restricted T Cells Anergized In Vivo

10.1084/jem.187.2.177

Crossref journal-article

Rockefeller University Press

The Journal of Experimental Medicine (291)

Abstract

Continuous antigenic stimulation in vivo can result in the generation of so-called “anergic” CD4+ or CD8+ T cells that fail to proliferate upon antigenic stimulation and fail to develop cytolytic effector functions. Here we show that class II major histocompatibility complex–restricted T cells specific for influenza hemagglutinin (HA) that become anergic in mice expressing HA under control of the immunoglobulin κ promoter exhibit an impaired effector function in causing diabetes in vivo, as compared to their naive counterparts, when transferred into immunodeficient recipients expressing HA under the control of the insulin promoter. Furthermore, HA-specific T cells anergized in vivo contain higher levels of interleukin (IL)-4 messenger RNA (mRNA) than naive and recently activated T cells with the same specificity and more than a 100-fold higher levels of IL-10 mRNA. The higher expression of the IL-10 gene is also evident at the protein level. These findings raise the interesting possibility that T cells rendered anergic in vivo have in fact become regulatory T cells that may influence neighboring immune responses through the release of IL-10.

Bibliography

Buer, J., Lanoue, A., Franzke, A., Garcia, C., Boehmer, H. von, & Sarukhan, A. (1998). Interleukin 10 Secretion and Impaired Effector Function of Major Histocompatibility Complex Class IIârestricted T Cells Anergized In Vivo. The Journal of Experimental Medicine, 187(2), 177â183.

Authors 6

Jan Buer (first)
Astrid Lanoue (additional)
Anke Franzke (additional)
Corinne Garcia (additional)
Harald von Boehmer (additional)
Adelaida Sarukhan (additional)

References 37 Referenced 175

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Dates

Type	When
Created	23 years, 1 month ago (July 26, 2002, 12:49 p.m.)
Deposited	2 years, 1 month ago (July 25, 2023, 4:41 a.m.)
Indexed	4 months, 4 weeks ago (March 31, 2025, 3:03 a.m.)
Issued	27 years, 7 months ago (Jan. 19, 1998)
Published	27 years, 7 months ago (Jan. 19, 1998)
Published Online	27 years, 7 months ago (Jan. 19, 1998)
Published Print	27 years, 7 months ago (Jan. 19, 1998)

Funders 0

None

BibTeX

@article{Buer_1998, title={Interleukin 10 Secretion and Impaired Effector Function of Major Histocompatibility Complex Class II–restricted T Cells Anergized In Vivo}, volume={187}, ISSN={1540-9538}, url={http://dx.doi.org/10.1084/jem.187.2.177}, DOI={10.1084/jem.187.2.177}, number={2}, journal={The Journal of Experimental Medicine}, publisher={Rockefeller University Press}, author={Buer, Jan and Lanoue, Astrid and Franzke, Anke and Garcia, Corinne and Boehmer, Harald von and Sarukhan, Adelaida}, year={1998}, month=jan, pages={177–183} }

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