DOI: 10.1084/jem.187.2.147. Mice Deficient in Nuclear Factor (NF)-κB/p52 Present with Defects in Humoral Responses, Germinal Center Reactions, and Splenic Microarchitecture

Mice Deficient in Nuclear Factor (NF)-κB/p52 Present with Defects in Humoral Responses, Germinal Center Reactions, and Splenic Microarchitecture

10.1084/jem.187.2.147

Crossref journal-article

Rockefeller University Press

The Journal of Experimental Medicine (291)

Abstract

p52 is a subunit of nuclear factor (NF)-κB transcription factors, most closely related to p50. Previously, we have shown that p52, but not p50 homodimers can form transactivating complexes when associated with Bcl-3, an unusual member of the IκB family. To determine nonredundant physiologic roles of p52, we generated mice deficient in p52. Null mutant mice were impaired in their ability to generate antibodies to T-dependent antigens, consistent with an absence of B cell follicles and follicular dendritic cell networks in secondary lymphoid organs, and an inability to form germinal centers. Furthermore, the splenic marginal zone was disrupted. These phenotypes are largely overlapping with those observed in Bcl-3 knockout animals, but distinct from those of p50 knockouts, supporting the notion of a physiologically relevant complex of p52 homodimers and Bcl-3. Adoptive transfer experiments further suggest that such a complex may be critical in accessory cell functions during antigen-specific immune reactions. Possible roles of p52 and Bcl-3 are discussed that may underlie the oncogenic potential of these proteins, as evidenced by recurrent chromosomal translocations of their genes in lymphoid tumors.

Bibliography

Franzoso, G., Carlson, L., Poljak, L., Shores, E. W., Epstein, S., Leonardi, A., Grinberg, A., Tran, T., Scharton-Kersten, T., Anver, M., Love, P., Brown, K., & Siebenlist, U. (1998). Mice Deficient in Nuclear Factor (NF)-ÎºB/p52 Present with Defects in Humoral Responses, Germinal Center Reactions, and Splenic Microarchitecture. The Journal of Experimental Medicine, 187(2), 147â159.

Authors 13

Guido Franzoso (first)
Louise Carlson (additional)
Ljiljana Poljak (additional)
Elizabeth W. Shores (additional)
Suzanne Epstein (additional)
Antonio Leonardi (additional)
Alex Grinberg (additional)
Tom Tran (additional)
Tanya Scharton-Kersten (additional)
Miriam Anver (additional)
Paul Love (additional)
Keith Brown (additional)
Ulrich Siebenlist (additional)

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Dates

Type	When
Created	23 years ago (July 26, 2002, 12:49 p.m.)
Deposited	2 years, 1 month ago (July 25, 2023, 4:49 a.m.)
Indexed	1 week, 5 days ago (Aug. 12, 2025, 5:35 p.m.)
Issued	27 years, 7 months ago (Jan. 19, 1998)
Published	27 years, 7 months ago (Jan. 19, 1998)
Published Online	27 years, 7 months ago (Jan. 19, 1998)
Published Print	27 years, 7 months ago (Jan. 19, 1998)

Funders 0

None

BibTeX

@article{Franzoso_1998, title={Mice Deficient in Nuclear Factor (NF)-κB/p52 Present with Defects in Humoral Responses, Germinal Center Reactions, and Splenic Microarchitecture}, volume={187}, ISSN={1540-9538}, url={http://dx.doi.org/10.1084/jem.187.2.147}, DOI={10.1084/jem.187.2.147}, number={2}, journal={The Journal of Experimental Medicine}, publisher={Rockefeller University Press}, author={Franzoso, Guido and Carlson, Louise and Poljak, Ljiljana and Shores, Elizabeth W. and Epstein, Suzanne and Leonardi, Antonio and Grinberg, Alex and Tran, Tom and Scharton-Kersten, Tanya and Anver, Miriam and Love, Paul and Brown, Keith and Siebenlist, Ulrich}, year={1998}, month=jan, pages={147–159} }

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