DOI: 10.1084/jem.186.3.353. Natural Killer Cell Tolerance in Mice with Mosaic Expression of Major Histocompatibility Complex Class I Transgene

Natural Killer Cell Tolerance in Mice with Mosaic Expression of Major Histocompatibility Complex Class I Transgene

10.1084/jem.186.3.353

Crossref journal-article

Rockefeller University Press

The Journal of Experimental Medicine (291)

Abstract

We have studied natural killer (NK) cell tolerance in a major histocompatibility complex (MHC) class I transgenic line, DL6, in which the transgene product was expressed on only a fraction of blood cells. In contrast with transgenic mice expressing the same transgene in all cells, NK cells from mosaic mice failed to reject transgene-negative bone marrow or lymphoma grafts. However, they retained the capability to reject cells with a total missing-self phenotype, i.e., cells lacking also wild-type MHC class I molecules. Tolerance against transgene-negative cells was demonstrated also in vitro, and could be broken if transgene-positive spleen cells of mosaic mice were separated from negative cells before, or after 4 d of culture in interleukin-2. The results provide support for selective NK cell tolerance to one particular missing-self phenotype but not to another. We suggest that this tolerance is determined by NK cell interactions with multiple cells in the environment, and that it is dominantly controlled by the presence of cells lacking a specific MHC class I ligand. Furthermore, the tolerant NK cells could be reactivated in vitro, which suggests that the tolerance occurs without deletion of the potentially autoreactive NK cell subset(s), and that it may be dependent upon the continuous presence of tolerizing cells.

Bibliography

Johansson, M. H., Bieberich, C., Jay, G., KÃ¤rre, K., & HÃ¶glund, P. (1997). Natural Killer Cell Tolerance in Mice with Mosaic Expression of Major Histocompatibility Complex Class I Transgene. The Journal of Experimental Medicine, 186(3), 353â364.

Authors 5

Maria H. Johansson (first)
Charles Bieberich (additional)
Gilbert Jay (additional)
Klas Kärre (additional)
Petter Höglund (additional)

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Dates

Type	When
Created	23 years, 1 month ago (July 26, 2002, 12:49 p.m.)
Deposited	2 years, 1 month ago (July 25, 2023, 4:17 a.m.)
Indexed	4 months, 3 weeks ago (April 10, 2025, 8:12 a.m.)
Issued	28 years ago (Aug. 4, 1997)
Published	28 years ago (Aug. 4, 1997)
Published Online	28 years ago (Aug. 4, 1997)
Published Print	28 years ago (Aug. 4, 1997)

Funders 0

None

BibTeX

@article{Johansson_1997, title={Natural Killer Cell Tolerance in Mice with Mosaic Expression of Major Histocompatibility Complex Class I Transgene}, volume={186}, ISSN={1540-9538}, url={http://dx.doi.org/10.1084/jem.186.3.353}, DOI={10.1084/jem.186.3.353}, number={3}, journal={The Journal of Experimental Medicine}, publisher={Rockefeller University Press}, author={Johansson, Maria H. and Bieberich, Charles and Jay, Gilbert and Kärre, Klas and Höglund, Petter}, year={1997}, month=aug, pages={353–364} }

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