DOI: 10.1084/jem.186.12.1957. Association with FcRγ Is Essential for Activation Signal through NKR-P1 (CD161) in Natural Killer (NK) Cells and NK1.1+ T Cells

Association with FcRγ Is Essential for Activation Signal through NKR-P1 (CD161) in Natural Killer (NK) Cells and NK1.1+ T Cells

10.1084/jem.186.12.1957

Crossref journal-article

Rockefeller University Press

The Journal of Experimental Medicine (291)

Abstract

Natural killer (NK) cells exhibit cytotoxicity against variety of tumor cells and virus-infected cells without prior sensitization and represent unique lymphocytes involved in primary host defense. NKR-P1 is thought to be one of NK receptors mediating activation signals because cross-linking of NKR-P1 activates NK cells to exhibit cytotoxicity and IFN-γ production. However, molecular mechanism of NK cell activation via NKR-P1 is not well elucidated. In this study, we analyzed the cell surface complex associated with NKR-P1 on NK cells and found that NKR-P1 associates with the FcRγ chain which is an essential component of Fc receptors for IgG and IgE. The association between FcRγ and NKR-P1 is independent of Fc receptor complexes. Furthermore, NK cells from FcRγ-deficient mice did not show cytotoxicity or IFN-γ production upon NKR-P1 cross-linking. Similarly, NK1.1+ T cells from FcRγ-deficient mice did not produce IFN-γ upon NKR-P1 crosslinking. These findings demonstrate that the FcRγ chain plays an important role in activation of NK cells via the NKR-P1 molecule.

Bibliography

Arase, N., Arase, H., Park, S. Y., Ohno, H., Ra, C., & Saito, T. (1997). Association with FcRÎ³ Is Essential for Activation Signal through NKR-P1 (CD161) in Natural Killer (NK) Cells and NK1.1+ T Cells. The Journal of Experimental Medicine, 186(12), 1957â1963.

Authors 6

Noriko Arase (first)
Hisashi Arase (additional)
Seung Yong Park (additional)
Hiroshi Ohno (additional)
Chisei Ra (additional)
Takashi Saito (additional)

References 38 Referenced 132

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Dates

Type	When
Created	23 years, 1 month ago (July 26, 2002, 12:49 p.m.)
Deposited	2 years, 1 month ago (July 25, 2023, 4:05 a.m.)
Indexed	1 week, 2 days ago (Aug. 26, 2025, 2:47 a.m.)
Issued	27 years, 8 months ago (Dec. 15, 1997)
Published	27 years, 8 months ago (Dec. 15, 1997)
Published Online	27 years, 8 months ago (Dec. 15, 1997)
Published Print	27 years, 8 months ago (Dec. 15, 1997)

Funders 0

None

BibTeX

@article{Arase_1997, title={Association with FcRγ Is Essential for Activation Signal through NKR-P1 (CD161) in Natural Killer (NK) Cells and NK1.1+ T Cells}, volume={186}, ISSN={1540-9538}, url={http://dx.doi.org/10.1084/jem.186.12.1957}, DOI={10.1084/jem.186.12.1957}, number={12}, journal={The Journal of Experimental Medicine}, publisher={Rockefeller University Press}, author={Arase, Noriko and Arase, Hisashi and Park, Seung Yong and Ohno, Hiroshi and Ra, Chisei and Saito, Takashi}, year={1997}, month=dec, pages={1957–1963} }

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