DOI: 10.1084/jem.186.11.1809. A Common Inhibitory Receptor for Major Histocompatibility Complex Class I Molecules on Human Lymphoid and Myelomonocytic Cells

A Common Inhibitory Receptor for Major Histocompatibility Complex Class I Molecules on Human Lymphoid and Myelomonocytic Cells

10.1084/jem.186.11.1809

Crossref journal-article

Rockefeller University Press

The Journal of Experimental Medicine (291)

Abstract

Natural killer (NK) cell–mediated lysis is negatively regulated by killer cell inhibitory receptors specific for major histocompatibility complex (MHC) class I molecules. In this study, we characterize a novel inhibitory MHC class I receptor of the immunoglobulin-superfamily, expressed not only by subsets of NK and T cells, but also by B cells, monocytes, macrophages, and dendritic cells. This receptor, called Ig-like transcript (ILT)2, binds MHC class I molecules and delivers a negative signal that inhibits killing by NK and T cells, as well as Ca2+ mobilization in B cells and myelomonocytic cells triggered through the B cell antigen receptor and human histocompatibility leukocyte antigens (HLA)–DR, respectively. In addition, myelomonocytic cells express receptors homologous to ILT2, which are characterized by extensive polymorphism and might recognize distinct HLA class I molecules. These results suggest that diverse leukocyte lineages have adopted recognition of self–MHC class I molecules as a common strategy to control cellular activation during an immune response.

Bibliography

Colonna, M., Navarro, F., BellÃ³n, T., Llano, M., GarcÃa, P., Samaridis, J., Angman, L., Cella, M., & LÃ³pez-Botet, M. (1997). A Common Inhibitory Receptor for Major Histocompatibility Complex Class I Molecules on Human Lymphoid and Myelomonocytic Cells. The Journal of Experimental Medicine, 186(11), 1809â1818.

Authors 9

Marco Colonna (first)
Francisco Navarro (additional)
Teresa Bellón (additional)
Manuel Llano (additional)
Pilar García (additional)
Jacqueline Samaridis (additional)
Lena Angman (additional)
Marina Cella (additional)
Miguel López-Botet (additional)

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{'key': '2023072507224039000_B12'}
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Dates

Type	When
Created	23 years, 1 month ago (July 26, 2002, 12:49 p.m.)
Deposited	2 years, 1 month ago (July 25, 2023, 4:01 a.m.)
Indexed	4 days, 3 hours ago (Aug. 28, 2025, 8:35 a.m.)
Issued	27 years, 9 months ago (Dec. 1, 1997)
Published	27 years, 9 months ago (Dec. 1, 1997)
Published Online	27 years, 9 months ago (Dec. 1, 1997)
Published Print	27 years, 9 months ago (Dec. 1, 1997)

Funders 0

None

BibTeX

@article{Colonna_1997, title={A Common Inhibitory Receptor for Major Histocompatibility Complex Class I Molecules on Human Lymphoid and Myelomonocytic Cells}, volume={186}, ISSN={1540-9538}, url={http://dx.doi.org/10.1084/jem.186.11.1809}, DOI={10.1084/jem.186.11.1809}, number={11}, journal={The Journal of Experimental Medicine}, publisher={Rockefeller University Press}, author={Colonna, Marco and Navarro, Francisco and Bellón, Teresa and Llano, Manuel and García, Pilar and Samaridis, Jacqueline and Angman, Lena and Cella, Marina and López-Botet, Miguel}, year={1997}, month=dec, pages={1809–1818} }

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