DOI: 10.1084/jem.186.10.1793. Signal Transduction Due to HIV-1 Envelope Interactions with Chemokine Receptors CXCR4 or CCR5

Signal Transduction Due to HIV-1 Envelope Interactions with Chemokine Receptors CXCR4 or CCR5

10.1084/jem.186.10.1793

Crossref journal-article

Rockefeller University Press

The Journal of Experimental Medicine (291)

Abstract

Infection with HIV-1 requires expression of CD4 and the chemokine receptors CXCR4 or CCR5 at the target cell surface. Engagement of these receptors by the HIV-1 envelope glycoprotein is essential for membrane fusion, but may additionally activate intracellular signaling pathways. In this study, we demonstrate that chemokines and HIV-1 envelope glycoproteins from both T-tropic and macrophage-tropic strains rapidly induce tyrosine phosphorylation of the protein tyrosine kinase Pyk2. The response requires CXCR4 and CCR5 to be accessible on the cell surface. The results presented here provide the first evidence for activation of an intracellular signaling event that can initiate multiple signaling pathways as a consequence of contact between HIV-1 and chemokine receptors.

Bibliography

Davis, C. B., Dikic, I., Unutmaz, D., Hill, C. M., Arthos, J., Siani, M. A., Thompson, D. A., Schlessinger, J., & Littman, D. R. (1997). Signal Transduction Due to HIV-1 Envelope Interactions with Chemokine Receptors CXCR4 or CCR5. The Journal of Experimental Medicine, 186(10), 1793â1798.

Authors 9

Craig B. Davis (first)
Ivan Dikic (additional)
Derya Unutmaz (additional)
C. Mark Hill (additional)
James Arthos (additional)
Michael A. Siani (additional)
Darren A. Thompson (additional)
Joseph Schlessinger (additional)
Dan R. Littman (additional)

References 35 Referenced 330

10.1038/40758 / Nature (Lond) / Spoilt for choice of co-receptors by Clapham (1997)
10.1038/384117a0 / Nature (Lond) / HIV. One on one meets two by Wain-Hobson (1996)
10.1038/382668a0 / Nature (Lond) / Natural resistance to HIV? by Hill (1996)
10.1038/384529a0 / Nature (Lond) / Host factors and the pathogenesis of HIV-induced disease by Fauci (1996)
10.1016/S0092-8674(00)80110-5 / Cell / Homozygous defect in HIV-1 coreceptor accounts for resistance of some multiply-exposed individuals to HIV-1 infection by Liu (1996)
10.1126/science.7973629 / Science (Wash DC) / Synthesis of proteins by native chemical ligation by Dawson (1994)
10.1073/pnas.88.2.512 / Proc Natl Acad Sci USA / Envelope glycoproteins from biologically diverse isolates of immunodeficiency viruses have widely different affinities for CD4 by Ivey-Hoyle (1991)
10.1038/384184a0 / Nature (Lond) / CD4-dependent, antibody-sensitive interactions between HIV-1 and its coreceptor CCR-5 by Trkola (1996)
10.1038/383547a0 / Nature (Lond) / A role for Pyk2 and Src in linking G-protein–coupled receptors with MAP kinase activation by Dikic (1996)
10.1038/381661a0 / Nature (Lond) / Identification of a major co-receptor for primary isolates of HIV-1 by Deng (1996)
10.1128/jvi.64.11.5360-5366.1990 / J Virol / Mutational analysis of the human immunodeficiency virus type 1 Rev transactivator: essential residues near the amino terminus by Hope (1990)
10.1006/viro.1995.1016 / Virology / Vpr is required for efficient replication of human immunodeficiency virus type–1 in mononuclear phagocytes by Connor (1995)
10.1016/1359-6101(96)00009-3 / Cytokine Growth Factor Rev / Chemokine receptors: structure, function, and role in microbial pathogenesis by Murphy (1996)
10.4049/jimmunol.155.5.2437 / J Immunol / RANTES-activated human T lymphocytes. A role for phosphoinositide 3-kinase by Turner (1995)
10.1038/376737a0 / Nature (Lond) / Protein tyrosine kinase PYK2 involved in Ca2+-induced regulation of ion channel and MAP kinase functions by Lev (1995)
10.1126/science.1902986 / Science (Wash DC) / Diversity of G proteins in signal transduction by Simon (1991)
10.1126/science.270.5243.1811 / Science (Wash DC) / Identification of RANTES, MIP-1α, and MIP-1β as the major HIV-suppressive factors produced by CD8+T cells by Cocchi (1995)
10.1038/382829a0 / Nature (Lond) / The lymphocyte chemoattractant SDF-1 is a ligand for LESTR/fusin and blocks HIV-1 entry by Bleul (1996)
10.1038/382833a0 / Nature (Lond) / The CXC chemokine SDF-1 is the ligand for LESTR/fusin and prevents infection by T-cell-line–adapted HIV-1 by Oberlin (1996)
10.1038/384179a0 / Nature (Lond) / CD4-induced interaction of primary HIV-1 gp120 glycoproteins with the chemokine receptor CCR-5 by Wu (1996)
10.1016/S0960-9822(06)00055-8 / Curr Biol / CD4-independent association between HIV-1 gp120 and CXCR4: functional chemokine receptors are expressed in human neurons by Hesselgesser (1997)
10.1038/348069a0 / Nature (Lond) / HIV-1 tropism for mononuclear phagocytes can be determined by regions of gp120 outside the CD4-binding domain by O'Brien (1990)
10.1006/viro.1993.1664 / Virology / Identification of HIV-1 determinants for T lymphoid cell line infection by Carrillo (1993)
10.1128/jvi.70.8.5487-5494.1996 / J Virol / Cell type-specific fusion cofactors determine human immunodeficiency virus type 1 tropism for T-cell lines versus primary macrophages by Alkhatib (1996)
{'key': '2023072507235576700_B25', 'first-page': '513', 'article-title': 'Involvement of carbohydrates in vesicular stomatitis virus-cell early interaction', 'volume': '33', 'author': 'Mastromarino', 'year': '1989', 'journal-title': 'Acta Virol'} / Acta Virol / Involvement of carbohydrates in vesicular stomatitis virus-cell early interaction by Mastromarino (1989)
10.1089/aid.1987.3.57 / AIDS Res Hum Retroviruses / Complete nucleotide sequences of functional clones of the AIDS virus by Ratner (1987)
10.1126/science.274.5287.602 / Science (Wash DC) / Evidence for cell-surface association between fusin and the CD4-gp120 complex in human cell lines by Lapham (1996)
10.1128/jvi.69.11.6904-6910.1995 / J Virol / The cytoplasmic tail of CD4 is required for inhibition of human immunodeficiency virus type 1 replication by antibodies that bind to the immunoglobulin CDR3–like region in domain 1 of CD4 by Benkirane (1995)
10.1128/jvi.70.6.4009-4016.1996 / J Virol / Repression of human immunodeficiency virus type 1 long terminal repeat–driven gene expression by binding of the virus to its primary cellular receptor, the CD4 molecule by Berube (1996)
10.1016/S0092-8674(00)81393-8 / Cell / CD4-Independent infection by HIV-2 is mediated by fusin/CXCR4 by Endres (1996)
10.1128/jvi.65.2.852-860.1991 / J Virol / Differential loss of envelope glycoprotein gp120 from virions of human immunodeficiency virus type 1 isolates: effects on infectivity and neutralization by McKeating (1991)
10.1038/nm1196-1244 / Nat Med / The V3 domain of the HIV-1 gp120 envelope glycoprotein is critical for chemokine-mediated blockade of infection by Cocchi (1996)
10.1074/jbc.272.11.6854 / J Biol Chem / HIV-1 entry and macrophage inflammatory protein– 1β–mediated signaling are independent functions of the chemokine receptor CCR5 by Farzan (1997)
10.1128/jvi.67.5.2807-2814.1993 / J Virol / Restricted replication of simian immunodeficiency virus strain 239 in macrophages is determined by Env but is not due to restricted entry by Mori (1993)
10.1126/science.273.5276.792 / Science (Wash DC) / Activation of Pyk2 by stress signals and coupling with JNK signaling pathway by Tokiwa (1996)

Dates

Type	When
Created	23 years, 1 month ago (July 26, 2002, 12:49 p.m.)
Deposited	2 years, 1 month ago (July 25, 2023, 4:01 a.m.)
Indexed	3 weeks, 1 day ago (Aug. 7, 2025, 4:51 a.m.)
Issued	27 years, 9 months ago (Nov. 17, 1997)
Published	27 years, 9 months ago (Nov. 17, 1997)
Published Online	27 years, 9 months ago (Nov. 17, 1997)
Published Print	27 years, 9 months ago (Nov. 17, 1997)

Funders 0

None

BibTeX

@article{Davis_1997, title={Signal Transduction Due to HIV-1 Envelope Interactions with Chemokine Receptors CXCR4 or CCR5}, volume={186}, ISSN={1540-9538}, url={http://dx.doi.org/10.1084/jem.186.10.1793}, DOI={10.1084/jem.186.10.1793}, number={10}, journal={The Journal of Experimental Medicine}, publisher={Rockefeller University Press}, author={Davis, Craig B. and Dikic, Ivan and Unutmaz, Derya and Hill, C. Mark and Arthos, James and Siani, Michael A. and Thompson, Darren A. and Schlessinger, Joseph and Littman, Dan R.}, year={1997}, month=nov, pages={1793–1798} }

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      "year": "1996",
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    {
      "key": "2023072507235576700_B3",
      "doi-asserted-by": "crossref",
      "first-page": "668",
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      "article-title": "Natural resistance to HIV?",
      "volume": "382",
      "author": "Hill",
      "year": "1996",
      "journal-title": "Nature (Lond)"
    },
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      "first-page": "529",
      "DOI": "10.1038/384529a0",
      "article-title": "Host factors and the pathogenesis of HIV-induced disease",
      "volume": "384",
      "author": "Fauci",
      "year": "1996",
      "journal-title": "Nature (Lond)"
    },
    {
      "key": "2023072507235576700_B5",
      "doi-asserted-by": "crossref",
      "first-page": "367",
      "DOI": "10.1016/S0092-8674(00)80110-5",
      "article-title": "Homozygous defect in HIV-1 coreceptor accounts for resistance of some multiply-exposed individuals to HIV-1 infection",
      "volume": "86",
      "author": "Liu",
      "year": "1996",
      "journal-title": "Cell"
    },
    {
      "key": "2023072507235576700_B6",
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      "first-page": "776",
      "DOI": "10.1126/science.7973629",
      "article-title": "Synthesis of proteins by native chemical ligation",
      "volume": "266",
      "author": "Dawson",
      "year": "1994",
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    {
      "key": "2023072507235576700_B7",
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      "first-page": "512",
      "DOI": "10.1073/pnas.88.2.512",
      "article-title": "Envelope glycoproteins from biologically diverse isolates of immunodeficiency viruses have widely different affinities for CD4",
      "volume": "88",
      "author": "Ivey-Hoyle",
      "year": "1991",
      "journal-title": "Proc Natl Acad Sci USA"
    },
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      "first-page": "184",
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      "author": "Trkola",
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      "volume": "348",
      "author": "O'Brien",
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      "author": "Carrillo",
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      "author": "Mastromarino",
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      "author": "Lapham",
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      "volume": "69",
      "author": "Benkirane",
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      "volume": "70",
      "author": "Berube",
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      "author": "Endres",
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      "volume": "65",
      "author": "McKeating",
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      "author": "Farzan",
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      "volume": "67",
      "author": "Mori",
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