DOI: 10.1084/jem.186.10.1769. Major Histocompatibility Complex Class I Molecules Modulate Activation Threshold and Early Signaling of T Cell Antigen Receptor

Major Histocompatibility Complex Class I Molecules Modulate Activation Threshold and Early Signaling of T Cell Antigen Receptor–γ/δ Stimulated by Nonpeptidic Ligands

10.1084/jem.186.10.1769

Crossref journal-article

Rockefeller University Press

The Journal of Experimental Medicine (291)

Abstract

Killer cell inhibitory receptors and CD94-NKG2-A/B heterodimers are major histocompatibility complex class I–specific inhibitory receptors expressed by natural killer cells, T cell antigen receptor (TCR)-γ/δ cells, and a subset of TCR-α/β cells. We studied the functional interaction between TCR-γ/δ and CD94, this inhibitory receptor being expressed on the majority of γ/δ T cells. When engaged by human histocompatibility leukocyte antigen class I molecules, CD94 downmodulates activation of human TCR-γ/δ by phosphorylated ligands. CD94-mediated inhibition is more effective at low than at high doses of TCR ligand, which may focus T cell responses towards antigen-presenting cells presenting high amounts of antigen. CD94 engagement has major effects on TCR signaling cascade. It facilitates recruitment of SHP-1 phosphatase to TCR–CD3 complex and affects phosphorylation of Lck and ZAP-70 kinase, but not of CD3 ζ chain upon TCR triggering. These events may cause abortion of proximal TCR-mediated signaling and set a higher TCR activation threshold.

Bibliography

Carena, I., Shamshiev, A., Donda, A., Colonna, M., & Libero, G. D. (1997). Major Histocompatibility Complex Class I Molecules Modulate Activation Threshold and Early Signaling of T Cell Antigen ReceptorâÎ³/Î´ Stimulated by Nonpeptidic Ligands. The Journal of Experimental Medicine, 186(10), 1769â1774.

Authors 5

Ilaria Carena (first)
Abdijapar Shamshiev (additional)
Alena Donda (additional)
Marco Colonna (additional)
Gennaro De Libero (additional)

References 33 Referenced 73

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Dates

Type	When
Created	23 years, 1 month ago (July 26, 2002, 12:49 p.m.)
Deposited	2 years, 1 month ago (July 25, 2023, 3:59 a.m.)
Indexed	3 months, 1 week ago (May 22, 2025, 2:46 a.m.)
Issued	27 years, 9 months ago (Nov. 17, 1997)
Published	27 years, 9 months ago (Nov. 17, 1997)
Published Online	27 years, 9 months ago (Nov. 17, 1997)
Published Print	27 years, 9 months ago (Nov. 17, 1997)

Funders 0

None

BibTeX

@article{Carena_1997, title={Major Histocompatibility Complex Class I Molecules Modulate Activation Threshold and Early Signaling of T Cell Antigen Receptor–γ/δ Stimulated by Nonpeptidic Ligands}, volume={186}, ISSN={1540-9538}, url={http://dx.doi.org/10.1084/jem.186.10.1769}, DOI={10.1084/jem.186.10.1769}, number={10}, journal={The Journal of Experimental Medicine}, publisher={Rockefeller University Press}, author={Carena, Ilaria and Shamshiev, Abdijapar and Donda, Alena and Colonna, Marco and Libero, Gennaro De}, year={1997}, month=nov, pages={1769–1774} }

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