DOI: 10.1084/jem.185.3.551. Viral Superantigen Drives Extrafollicular and Follicular B Cell Differentiation Leading to Virus-specific Antibody Production

Viral Superantigen Drives Extrafollicular and Follicular B Cell Differentiation Leading to Virus-specific Antibody Production

10.1084/jem.185.3.551

Crossref journal-article

Rockefeller University Press

The Journal of Experimental Medicine (291)

Abstract

Mouse mammary tumor virus (MMTV[SW]) encodes a superantigen expressed by infected B cells. It evokes an antibody response specific for viral envelope protein, indicating selective activation of antigen-specific B cells. The response to MMTV(SW) in draining lymph nodes was compared with the response to haptenated chicken gamma globulin (NP-CGG) using flow cytometry and immunohistology. T cell priming occurs in both responses, with T cells proliferating in association with interdigitating dendritic cells in the T zone. T cell proliferation continues in the presence of B cells in the outer T zone, and B blasts then undergo exponential growth and differentiation into plasma cells in the medullary cords. Germinal centers develop in both responses, but those induced by MMTV(SW) appear later and are smaller. Most T cells activated in the T zone and germinal centers in the MMTV(SW) response are superantigen specific and these persist for weeks in lymph nodes draining the site MMTV(SW) injection; this contrasts with the selective loss of superantigen-specific T cells from other secondary lymphoid tissues. The results indicate that this viral superantigen, when expressed by professional antigen-presenting cells, drives extrafollicular and follicular B cell differentiation leading to virus-specific antibody production.

Bibliography

Luther, S. A., Gulbranson-Judge, A., Acha-Orbea, H., & MacLennan, I. C. M. (1997). Viral Superantigen Drives Extrafollicular and Follicular B Cell Differentiation Leading to Virus-specific Antibody Production. The Journal of Experimental Medicine, 185(3), 551â562.

Authors 4

Sanjiv A. Luther (first)
Adam Gulbranson-Judge (additional)
Hans Acha-Orbea (additional)
Ian C.M. MacLennan (additional)

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Dates

Type	When
Created	23 years, 1 month ago (July 26, 2002, 12:49 p.m.)
Deposited	2 years, 1 month ago (July 25, 2023, 3:57 a.m.)
Indexed	1 week, 2 days ago (Aug. 27, 2025, 11:58 a.m.)
Issued	28 years, 7 months ago (Feb. 3, 1997)
Published	28 years, 7 months ago (Feb. 3, 1997)
Published Online	28 years, 7 months ago (Feb. 3, 1997)
Published Print	28 years, 7 months ago (Feb. 3, 1997)

Funders 0

None

BibTeX

@article{Luther_1997, title={Viral Superantigen Drives Extrafollicular and Follicular B Cell Differentiation Leading to Virus-specific Antibody Production}, volume={185}, ISSN={1540-9538}, url={http://dx.doi.org/10.1084/jem.185.3.551}, DOI={10.1084/jem.185.3.551}, number={3}, journal={The Journal of Experimental Medicine}, publisher={Rockefeller University Press}, author={Luther, Sanjiv A. and Gulbranson-Judge, Adam and Acha-Orbea, Hans and MacLennan, Ian C.M.}, year={1997}, month=feb, pages={551–562} }

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