DOI: 10.1084/jem.184.6.2429. Dendritic Cells Are Recruited into the Airway Epithelium during the Inflammatory Response to a Broad Spectrum of Stimuli

Dendritic Cells Are Recruited into the Airway Epithelium during the Inflammatory Response to a Broad Spectrum of Stimuli

10.1084/jem.184.6.2429

Crossref journal-article

Rockefeller University Press

The Journal of Experimental Medicine (291)

Abstract

A key rate-limiting step in the adaptive immune response at peripheral challenge sites is the transmission of antigen signals to T cells in regional lymph nodes. Recent evidence suggests that specialized dendritic cells (DC) fulfill this surveillance function in the resting state, but their relatively slow turnover in most peripheral tissues brings into question their effectiveness in signaling the arrival of highly pathogenic sources of antigen which require immediate mobilization of the full range of host defenses for maintenance of homeostasis. However, the present report demonstrates that recruitment of a wave of DC into the respiratory tract mucosa is a universal feature of the acute cellular response to local challenge with bacterial, viral, and soluble protein antigens. Consistent with this finding, we also demonstrate that freshly isolated respiratory mucosal DC respond in vitro to a variety of CC chemokines as well as complementary cleavage products and N-formyl-methionyl-leucine-phenylalanine. This suggests that rapid amplification of specific antigen surveillance at peripheral challenge sites is an integral feature of the innate immune response at mucosal surfaces, and serves as an “early warning system” to alert the adaptive immune system to incoming pathogens.

Bibliography

McWilliam, A. S., Napoli, S., Marsh, A. M., Pemper, F. L., Nelson, D. J., Pimm, C. L., Stumbles, P. A., Wells, T. N. C., & Holt, P. G. (1996). Dendritic Cells Are Recruited into the Airway Epithelium during the Inflammatory Response to a Broad Spectrum of Stimuli. The Journal of Experimental Medicine, 184(6), 2429â2432.

Authors 9

Andrew S. McWilliam (first)
Sylvia Napoli (additional)
Amanda M. Marsh (additional)
Francis L. Pemper (additional)
Delia J. Nelson (additional)
Carolyn L. Pimm (additional)
Philip A. Stumbles (additional)
Timothy N.C. Wells (additional)
Patrick G. Holt (additional)

References 15 Referenced 248

10.1016/0167-5699(92)90198-G / Immunol Today / The immune response evolved to discriminate infectious nonself from noninfectious self by Janeway (1992)
10.1146/annurev.iy.09.040191.001415 / Annu Rev Immunol / The dendritic cell system and its role in immunogenicity by Steinman (1991)
10.1084/jem.167.2.262 / J Exp Med / MHC class II antigen-bearing dendritic cells in pulmonary tissues of the rat: regulation of antigen presentation activity by endogenous macrophage populations by Holt (1988)
10.1084/jem.173.6.1345 / J Exp Med / Studies on the density, distribution, and surface phenotype of intraepithelial class II MHC antigen (Ia)-bearing dendritic cells (DC) in the conducting airways by Schon-Hegrad (1991)
10.1084/jem.154.2.347 / J Exp Med / Demonstration and characterization of Ia-positive dendritic cells in the interstitial connective tissues of rat heart and other tissues, but not brain by Hart (1981)
10.1111/1523-1747.ep12275627 / J Invest Dermatol / Occurrence of donor Langerhans cells in mouse and rat chimeras and their replacement in skin grafts by Chen (1986)
10.1016/0923-2494(89)90048-5 / Res Immunol / Dendritic leukocytes: features of their in vivophysiology by Fossum (1989)
10.4049/jimmunol.153.1.256 / J Immunol / Origin and steady-state turnover of class II MHC-bearing dendritic cells in the epithelium of the conducting airways by Holt (1994)
10.1111/j.1600-065X.1983.tb01084.x / Immunol Rev / Functions of rat T-lymphocyte subsets isolated by means of monoclonal antibodies by Mason (1983)
10.1084/jem.169.1.73 / J Exp Med / A monoclonal antibody to a constant determinant of the rat T cell antigen receptor that induces T cell activation. Differential reactivity with subsets of immature and mature T lymphocytes by Hünig (1989)
10.1002/jlb.46.6.556 / J Leukocyte Biol / Heterogeneity of macrophages in the rat evidenced by variability in determinants: two new anti–rat macrophage antibodies against a heterodimer of 160 and 95 kd (CD11/CD18) by Damoiseaux (1989)
10.1002/jlb.46.2.96 / J Leukocyte Biol / Selective depletion of rat neutrophils by in vivo administration of a monoclonal antibody by Sekiya (1989)
10.1084/jem.179.4.1331 / J Exp Med / Rapid dendritic cell recruitment is a hallmark of the acute inflammatory response at mucosal surfaces by McWilliam (1994)
10.4049/jimmunol.155.7.3292 / J Immunol / Migration of dendritic cells in response to formyl peptides, C5a, and a distinct set of chemokines by Sozzani (1995)
10.1016/0167-5699(95)80118-9 / Immunol Today / The injured cell: the role of the dendritic cell system as a sentinel receptor pathway by Ibrahim (1995)

Dates

Type	When
Created	21 years, 2 months ago (June 24, 2004, 3:56 a.m.)
Deposited	2 years, 1 month ago (July 28, 2023, 3:53 p.m.)
Indexed	1 week, 3 days ago (Aug. 23, 2025, 1 a.m.)
Issued	28 years, 9 months ago (Dec. 1, 1996)
Published	28 years, 9 months ago (Dec. 1, 1996)
Published Online	28 years, 9 months ago (Dec. 1, 1996)
Published Print	28 years, 9 months ago (Dec. 1, 1996)

Funders 0

None

BibTeX

@article{McWilliam_1996, title={Dendritic Cells Are Recruited into the Airway Epithelium during the Inflammatory Response to a Broad Spectrum of Stimuli}, volume={184}, ISSN={1540-9538}, url={http://dx.doi.org/10.1084/jem.184.6.2429}, DOI={10.1084/jem.184.6.2429}, number={6}, journal={The Journal of Experimental Medicine}, publisher={Rockefeller University Press}, author={McWilliam, Andrew S. and Napoli, Sylvia and Marsh, Amanda M. and Pemper, Francis L. and Nelson, Delia J. and Pimm, Carolyn L. and Stumbles, Philip A. and Wells, Timothy N.C. and Holt, Patrick G.}, year={1996}, month=dec, pages={2429–2432} }

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