DOI: 10.1084/jem.184.3.955. Identification of a costimulatory molecule rapidly induced by CD40L as CD44H.

Identification of a costimulatory molecule rapidly induced by CD40L as CD44H.

10.1084/jem.184.3.955

Crossref journal-article

Rockefeller University Press

The Journal of experimental medicine (291)

Abstract

The interaction between CD40 ligand and CD40 is critical for activation of T and B cells in vivo. We have recently demonstrated that this interaction rapidly induces a novel costimulatory activity distinct from B7 and independent of CD28. To study the molecular basis of the costimulatory activity, we have produced a novel monoclonal antibody, TM-1, that binds an 85-kilodalton costimulatory molecule rapidly induced by CD40L. Expression cloning reveals that TM-1 binds CD44H. CD44H expressed on Chinese hamster ovary cells has potent costimulatory activity for clonal expansion of T cells isolated from both wild-type mice and these with a targeted mutation of CD28. Thus, CD44H costimulates T cell proliferation by a CD28-independent mechanism. These results revealed that CD44H is a costimulatory molecule rapidly induced by CD40L.

Bibliography

Guo, Y., Wu, Y., Shinde, S., Sy, M. S., Aruffo, A., & Liu, Y. (1996). Identification of a costimulatory molecule rapidly induced by CD40L as CD44H. The Journal of Experimental Medicine, 184(3), 955â961.

Authors 6

Y Guo (first)
Y Wu (additional)
S Shinde (additional)
M S Sy (additional)
A Aruffo (additional)
Y Liu (additional)

References 0 Referenced 83

None

Dates

Type	When
Created	21 years, 2 months ago (June 24, 2004, 3:56 a.m.)
Deposited	2 years, 1 month ago (July 25, 2023, 3:19 a.m.)
Indexed	4 months, 4 weeks ago (March 31, 2025, 11:04 a.m.)
Issued	28 years, 11 months ago (Sept. 1, 1996)
Published	28 years, 11 months ago (Sept. 1, 1996)
Published Online	28 years, 11 months ago (Sept. 1, 1996)
Published Print	28 years, 11 months ago (Sept. 1, 1996)

Funders 0

None

BibTeX

@article{Guo_1996, title={Identification of a costimulatory molecule rapidly induced by CD40L as CD44H.}, volume={184}, ISSN={1540-9538}, url={http://dx.doi.org/10.1084/jem.184.3.955}, DOI={10.1084/jem.184.3.955}, number={3}, journal={The Journal of experimental medicine}, publisher={Rockefeller University Press}, author={Guo, Y and Wu, Y and Shinde, S and Sy, M S and Aruffo, A and Liu, Y}, year={1996}, month=sep, pages={955–961} }

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