DOI: 10.1084/jem.184.1.93. Tyrosine phosphorylation of a human killer inhibitory receptor recruits protein tyrosine phosphatase 1C.

Tyrosine phosphorylation of a human killer inhibitory receptor recruits protein tyrosine phosphatase 1C.

10.1084/jem.184.1.93

Crossref journal-article

Rockefeller University Press

The Journal of experimental medicine (291)

Abstract

Natural killer (NK) cells express killer inhibitory receptors that mediate negative regulation of NK cell cytotoxicity upon binding to MHC class I molecules on target cells. Unrelated inhibitory receptors on B cells have recently been shown to function through recruitment of phosphotyrosine phosphatase 1C (PTP-1C). Here, we show that a human killer inhibitory receptor specific for HLA-C also recruits PTP-1C after phosphorylation induced either by the pharmacological agent phenylarsine oxide or by conjugation with target cells. This recruitment is mediated by the binding of specific cytoplasmic phosphotyrosine-containing sequences to PTP-1C. These results implicate PTP-1C as a cytosolic component of the negative signaling pathway through NK cell inhibitory receptors.

Bibliography

Campbell, K. S., Dessing, M., Lopez-Botet, M., Cella, M., & Colonna, M. (1996). Tyrosine phosphorylation of a human killer inhibitory receptor recruits protein tyrosine phosphatase 1C. The Journal of Experimental Medicine, 184(1), 93â100.

Authors 5

K S Campbell (first)
M Dessing (additional)
M Lopez-Botet (additional)
M Cella (additional)
M Colonna (additional)

References 0 Referenced 173

None

Dates

Type	When
Created	21 years, 2 months ago (June 24, 2004, 3:56 a.m.)
Deposited	2 years, 1 month ago (July 25, 2023, 3:15 a.m.)
Indexed	1 month ago (July 28, 2025, 5:46 p.m.)
Issued	29 years, 1 month ago (July 1, 1996)
Published	29 years, 1 month ago (July 1, 1996)
Published Online	29 years, 1 month ago (July 1, 1996)
Published Print	29 years, 1 month ago (July 1, 1996)

Funders 0

None

BibTeX

@article{Campbell_1996, title={Tyrosine phosphorylation of a human killer inhibitory receptor recruits protein tyrosine phosphatase 1C.}, volume={184}, ISSN={1540-9538}, url={http://dx.doi.org/10.1084/jem.184.1.93}, DOI={10.1084/jem.184.1.93}, number={1}, journal={The Journal of experimental medicine}, publisher={Rockefeller University Press}, author={Campbell, K S and Dessing, M and Lopez-Botet, M and Cella, M and Colonna, M}, year={1996}, month=jul, pages={93–100} }

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