DOI: 10.1084/jem.182.6.1655. CD30-mediated signaling promotes the development of human T helper type 2-like T cells.

CD30-mediated signaling promotes the development of human T helper type 2-like T cells.

10.1084/jem.182.6.1655

Crossref journal-article

Rockefeller University Press

The Journal of experimental medicine (291)

Abstract

We have recently shown that CD30, a member of the tumor necrosis factor/nerve growth factor receptor superfamily, is preferentially expressed by human T cell clones producing T helper (Th) type 2 cytokines. We report here that costimulation with an agonistic anti-CD30 monoclonal antibody enhanced antigen (Ag)-induced proliferation and cytokine secretion by established human Th2 and Th0 clones. Moreover, costimulation of peripheral blood mononuclear cells with the same anti-CD30 monoclonal antibody resulted in the preferential development of Ag-specific T cell lines and clones showing a Th2-like profile of cytokine secretion. In contrast, early blockade in bulk culture of CD30 ligand-CD30 interaction shifted the development of Ag-specific T cells towards the opposite (Th1-like) phenotype. Taken together, these data suggest that CD30 triggering of activated Th cells by CD30 ligand-expressing Ag-presenting cells may represent an important costimulatory signaling for the development of Th2-type responses.

Bibliography

Del Prete, G., De Carli, M., DâElios, M. M., Daniel, K. C., Almerigogna, F., Alderson, M., Smith, C. A., Thomas, E., & Romagnani, S. (1995). CD30-mediated signaling promotes the development of human T helper type 2-like T cells. The Journal of Experimental Medicine, 182(6), 1655â1661.

Authors 9

G Del Prete (first)
M De Carli (additional)
M M D'Elios (additional)
K C Daniel (additional)
F Almerigogna (additional)
M Alderson (additional)
C A Smith (additional)
E Thomas (additional)
S Romagnani (additional)

References 0 Referenced 126

None

Dates

Type	When
Created	21 years, 2 months ago (June 24, 2004, 3:56 a.m.)
Deposited	2 years, 1 month ago (July 25, 2023, 3:05 a.m.)
Indexed	4 months, 4 weeks ago (March 31, 2025, 11:48 a.m.)
Issued	29 years, 8 months ago (Dec. 1, 1995)
Published	29 years, 8 months ago (Dec. 1, 1995)
Published Online	29 years, 8 months ago (Dec. 1, 1995)
Published Print	29 years, 8 months ago (Dec. 1, 1995)

Funders 0

None

BibTeX

@article{Del_Prete_1995, title={CD30-mediated signaling promotes the development of human T helper type 2-like T cells.}, volume={182}, ISSN={1540-9538}, url={http://dx.doi.org/10.1084/jem.182.6.1655}, DOI={10.1084/jem.182.6.1655}, number={6}, journal={The Journal of experimental medicine}, publisher={Rockefeller University Press}, author={Del Prete, G and De Carli, M and D’Elios, M M and Daniel, K C and Almerigogna, F and Alderson, M and Smith, C A and Thomas, E and Romagnani, S}, year={1995}, month=dec, pages={1655–1661} }

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