DOI: 10.1084/jem.182.5.1337. Migration of monocytes across endothelium and passage through extracellular matrix involve separate molecular domains of PECAM-1.

Migration of monocytes across endothelium and passage through extracellular matrix involve separate molecular domains of PECAM-1.

10.1084/jem.182.5.1337

Crossref journal-article

Rockefeller University Press

The Journal of experimental medicine (291)

Abstract

During the inflammatory response, the adhesion molecule PECAM plays a crucial role in transendothelial migration, the passage of leukocytes across endothelium. We report here an additional role for PECAM in the subsequent migration of monocytes through the subendothelial extracellular matrix. PECAM has six immunoglobulin (Ig) superfamily domains. Monoclonal antibodies whose epitopes map to domains 1 and/or 2 selectively block monocyte migration through the endothelial junction, whereas those that map to domain 6 block only the migration through the extracellular matrix, trapping the monocyte between the endothelium and its basal lamina. Therefore, transendothelial migration (diapedesis) and passage through extracellular matrix (interstitial migration) are distinct and separable phases of monocyte emigration. Furthermore, distinct and separate Ig domains of PECAM are involved in mediating these two steps.

Bibliography

Liao, F., Huynh, H. K., Eiroa, A., Greene, T., Polizzi, E., & Muller, W. A. (1995). Migration of monocytes across endothelium and passage through extracellular matrix involve separate molecular domains of PECAM-1. The Journal of Experimental Medicine, 182(5), 1337â1343.

Authors 6

F Liao (first)
H K Huynh (additional)
A Eiroa (additional)
T Greene (additional)
E Polizzi (additional)
W A Muller (additional)

References 0 Referenced 180

None

Dates

Type	When
Created	21 years, 2 months ago (June 24, 2004, 3:56 a.m.)
Deposited	2 years, 1 month ago (July 25, 2023, 3:02 a.m.)
Indexed	1 month ago (July 24, 2025, 7:14 a.m.)
Issued	29 years, 9 months ago (Nov. 1, 1995)
Published	29 years, 9 months ago (Nov. 1, 1995)
Published Online	29 years, 9 months ago (Nov. 1, 1995)
Published Print	29 years, 9 months ago (Nov. 1, 1995)

Funders 0

None

BibTeX

@article{Liao_1995, title={Migration of monocytes across endothelium and passage through extracellular matrix involve separate molecular domains of PECAM-1.}, volume={182}, ISSN={1540-9538}, url={http://dx.doi.org/10.1084/jem.182.5.1337}, DOI={10.1084/jem.182.5.1337}, number={5}, journal={The Journal of experimental medicine}, publisher={Rockefeller University Press}, author={Liao, F and Huynh, H K and Eiroa, A and Greene, T and Polizzi, E and Muller, W A}, year={1995}, month=nov, pages={1337–1343} }

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