DOI: 10.1084/jem.181.4.1519. Lymphopenia in interleukin (IL)-7 gene-deleted mice identifies IL-7 as a nonredundant cytokine.

Lymphopenia in interleukin (IL)-7 gene-deleted mice identifies IL-7 as a nonredundant cytokine.

10.1084/jem.181.4.1519

Crossref journal-article

Rockefeller University Press

The Journal of experimental medicine (291)

Abstract

Interleukin (IL)-7 is a potent stimulus for immature T and B cells and, to a lesser extent, mature T cells. We have inactivated the IL-7 gene in the mouse germline by using gene-targeting techniques to further understand the biology of IL-7. Mutant mice were highly lymphopenic in the peripheral blood and lymphoid organs. Bone marrow B lymphopoiesis was blocked at the transition from pro-B to pre-B cells. Thymic cellularity was reduced 20-fold, but retained normal distribution of CD4 and CD8. Splenic T cellularity was reduced 10-fold. Splenic B cells, also reduced in number, showed an abnormal population of immature B cells in adult animals. The remaining splenic populations of lymphocytes showed normal responsiveness to mitogenic stimuli. These data show that proper T and B cell development is dependent on IL-7. The IL-7-deficient mice are the first example of single cytokine-deficient mice that exhibit severe lymphoid abnormalities.

Bibliography

von Freeden-Jeffry, U., Vieira, P., Lucian, L. A., McNeil, T., Burdach, S. E., & Murray, R. (1995). Lymphopenia in interleukin (IL)-7 gene-deleted mice identifies IL-7 as a nonredundant cytokine. The Journal of Experimental Medicine, 181(4), 1519â1526.

Authors 6

U von Freeden-Jeffry (first)
P Vieira (additional)
L A Lucian (additional)
T McNeil (additional)
S E Burdach (additional)
R Murray (additional)

References 0 Referenced 1,161

None

Dates

Type	When
Created	21 years, 2 months ago (June 24, 2004, 3:56 a.m.)
Deposited	2 years, 1 month ago (July 25, 2023, 2:43 a.m.)
Indexed	1 hour, 18 minutes ago (Sept. 3, 2025, 5:40 a.m.)
Issued	30 years, 5 months ago (April 1, 1995)
Published	30 years, 5 months ago (April 1, 1995)
Published Online	30 years, 5 months ago (April 1, 1995)
Published Print	30 years, 5 months ago (April 1, 1995)

Funders 0

None

BibTeX

@article{von_Freeden_Jeffry_1995, title={Lymphopenia in interleukin (IL)-7 gene-deleted mice identifies IL-7 as a nonredundant cytokine.}, volume={181}, ISSN={1540-9538}, url={http://dx.doi.org/10.1084/jem.181.4.1519}, DOI={10.1084/jem.181.4.1519}, number={4}, journal={The Journal of experimental medicine}, publisher={Rockefeller University Press}, author={von Freeden-Jeffry, U and Vieira, P and Lucian, L A and McNeil, T and Burdach, S E and Murray, R}, year={1995}, month=apr, pages={1519–1526} }

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