DOI: 10.1084/jem.180.4.1511. Retroviral infection of neonatal Peyer's patch lymphocytes: the mouse mammary tumor virus model.

Retroviral infection of neonatal Peyer's patch lymphocytes: the mouse mammary tumor virus model.

10.1084/jem.180.4.1511

Crossref journal-article

Rockefeller University Press

The Journal of experimental medicine (291)

Abstract

Mouse mammary tumor virus is known to infect newborn mice via mother's milk. A proposed key step for viral spread to the mammary gland is by the infection of lymphocytes. We show here that although in suckling mice retroviral proteins are found in all epithelial cells of the gut, viral DNA is exclusively detectable in the Peyer's patches. As early as 5 d after birth the infection leads to a superantigen response in the Peyer's patches but not in other lymphoid organs draining the intestine. Viral DNA can be detected before the superantigen response and becomes first evident in the Peyer's patches followed by mesenteric lymph nodes and finally all lymphoid organs.

Bibliography

Karapetian, O., Shakhov, A. N., Kraehenbuhl, J. P., & Acha-Orbea, H. (1994). Retroviral infection of neonatal Peyerâs patch lymphocytes: the mouse mammary tumor virus model. The Journal of Experimental Medicine, 180(4), 1511â1516.

Authors 4

O Karapetian (first)
A N Shakhov (additional)
J P Kraehenbuhl (additional)
H Acha-Orbea (additional)

References 0 Referenced 51

None

Dates

Type	When
Created	21 years, 2 months ago (June 24, 2004, 3:56 a.m.)
Deposited	2 years, 1 month ago (July 25, 2023, 2:14 a.m.)
Indexed	2 days, 15 hours ago (Sept. 3, 2025, 7:02 a.m.)
Issued	30 years, 11 months ago (Oct. 1, 1994)
Published	30 years, 11 months ago (Oct. 1, 1994)
Published Online	30 years, 11 months ago (Oct. 1, 1994)
Published Print	30 years, 11 months ago (Oct. 1, 1994)

Funders 0

None

BibTeX

@article{Karapetian_1994, title={Retroviral infection of neonatal Peyer’s patch lymphocytes: the mouse mammary tumor virus model.}, volume={180}, ISSN={1540-9538}, url={http://dx.doi.org/10.1084/jem.180.4.1511}, DOI={10.1084/jem.180.4.1511}, number={4}, journal={The Journal of experimental medicine}, publisher={Rockefeller University Press}, author={Karapetian, O and Shakhov, A N and Kraehenbuhl, J P and Acha-Orbea, H}, year={1994}, month=oct, pages={1511–1516} }

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