DOI: 10.1084/jem.177.2.443. Prevention of tumor metastasis formation by anti-variant CD44.

Prevention of tumor metastasis formation by anti-variant CD44.

10.1084/jem.177.2.443

Crossref journal-article

Rockefeller University Press

The Journal of experimental medicine (291)

Abstract

A splice variant of CD44 (CD44v) originally discovered on metastases of a rat pancreatic adenocarcinoma (BSp73ASML) has been shown by transfection to confer metastatic behavior to nonmetastatic tumor cells (Günthert U., M. Hofmann, W. Rudy, S. Reber, M. Zöller, I. Haussmann, S. Matzku, A. Wenzel, H. Ponta, and P. Herrlich. 1991. Cell. 65:13). A monoclonal antibody (mAb), 1.1ASML, to the metastasis-specific domain of the CD44v molecule retards growth of lymph node and lung metastases of the metastatic tumor line BSp73ASML, and can efficiently prevent formation of metastases by the transfected line. The antibody is only effective when given before lymph node colonization. Anti-CD44v does not downregulate the expression of CD44v, and prevention of metastatic growth by anti-CD44v is not due to activation of any kind of immune defense. We suggest that the mAb interferes with proliferation of metastasizing tumor cells in the draining lymph node, most probably by blocking a ligand interaction. The interference with metastatic spread will greatly facilitate the exploration of the function of CD44v and, in particular, may also open new strategies for the therapy of human metastases.

Bibliography

Seiter, S., Arch, R., Reber, S., Komitowski, D., Hofmann, M., Ponta, H., Herrlich, P., Matzku, S., & ZÃ¶ller, M. (1993). Prevention of tumor metastasis formation by anti-variant CD44. The Journal of Experimental Medicine, 177(2), 443â455.

Authors 9

S Seiter (first)
R Arch (additional)
S Reber (additional)
D Komitowski (additional)
M Hofmann (additional)
H Ponta (additional)
P Herrlich (additional)
S Matzku (additional)
M Zöller (additional)

References 0 Referenced 235

None

Dates

Type	When
Created	21 years, 2 months ago (June 24, 2004, 3:56 a.m.)
Deposited	2 years, 1 month ago (July 25, 2023, 12:52 a.m.)
Indexed	4 weeks ago (Aug. 7, 2025, 4:53 a.m.)
Issued	32 years, 7 months ago (Feb. 1, 1993)
Published	32 years, 7 months ago (Feb. 1, 1993)
Published Online	32 years, 7 months ago (Feb. 1, 1993)
Published Print	32 years, 7 months ago (Feb. 1, 1993)

Funders 0

None

BibTeX

@article{Seiter_1993, title={Prevention of tumor metastasis formation by anti-variant CD44.}, volume={177}, ISSN={1540-9538}, url={http://dx.doi.org/10.1084/jem.177.2.443}, DOI={10.1084/jem.177.2.443}, number={2}, journal={The Journal of experimental medicine}, publisher={Rockefeller University Press}, author={Seiter, S and Arch, R and Reber, S and Komitowski, D and Hofmann, M and Ponta, H and Herrlich, P and Matzku, S and Zöller, M}, year={1993}, month=feb, pages={443–455} }

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