DOI: 10.1084/jem.176.4.1215. Functional expression of the costimulatory molecule, B7/BB1, on murine dendritic cell populations.

Functional expression of the costimulatory molecule, B7/BB1, on murine dendritic cell populations.

10.1084/jem.176.4.1215

Crossref journal-article

Rockefeller University Press

The Journal of experimental medicine (291)

Abstract

Whereas dendritic cells (DC) are known to be potent activators of T cells both in vitro and in vivo, the critical costimulatory molecules expressed on DC are not well characterized. Using immunocytochemical and molecular techniques we find that splenic DC express B7/BB1, the counter-receptor for CD28. Moreover, expression of B7/BB1 is upregulated on epidermal Langerhans cells (LC) during their functional maturation into potent T cell stimulators. In blocking experiments, we find that participation of B7/BB1 is required for optimal proliferation of unprimed, allogeneic T cells in DC-driven, primary mixed leukocyte reactions. These data demonstrate that the regulated expression of B7/BB1 on DC may be important in the initiation of a primary T cell response.

Bibliography

Larsen, C. P., Ritchie, S. C., Pearson, T. C., Linsley, P. S., & Lowry, R. P. (1992). Functional expression of the costimulatory molecule, B7/BB1, on murine dendritic cell populations. The Journal of Experimental Medicine, 176(4), 1215â1220.

Authors 5

C P Larsen (first)
S C Ritchie (additional)
T C Pearson (additional)
P S Linsley (additional)
R P Lowry (additional)

References 0 Referenced 196

None

Dates

Type	When
Created	21 years, 2 months ago (June 24, 2004, 3:56 a.m.)
Deposited	2 years, 1 month ago (July 25, 2023, 12:46 a.m.)
Indexed	1 month, 1 week ago (July 24, 2025, 7:06 a.m.)
Issued	32 years, 11 months ago (Oct. 1, 1992)
Published	32 years, 11 months ago (Oct. 1, 1992)
Published Online	32 years, 11 months ago (Oct. 1, 1992)
Published Print	32 years, 11 months ago (Oct. 1, 1992)

Funders 0

None

BibTeX

@article{Larsen_1992, title={Functional expression of the costimulatory molecule, B7/BB1, on murine dendritic cell populations.}, volume={176}, ISSN={1540-9538}, url={http://dx.doi.org/10.1084/jem.176.4.1215}, DOI={10.1084/jem.176.4.1215}, number={4}, journal={The Journal of experimental medicine}, publisher={Rockefeller University Press}, author={Larsen, C P and Ritchie, S C and Pearson, T C and Linsley, P S and Lowry, R P}, year={1992}, month=oct, pages={1215–1220} }

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