DOI: 10.1084/jem.175.5.1401. A heterophilic adhesion mechanism for platelet/endothelial cell adhesion molecule 1 (CD31).

A heterophilic adhesion mechanism for platelet/endothelial cell adhesion molecule 1 (CD31).

10.1084/jem.175.5.1401

Crossref journal-article

Rockefeller University Press

The Journal of experimental medicine (291)

Abstract

The molecular nature of cell adhesion mediated by platelet/endothelial cell adhesion molecule 1 (PECAM-1; CD31) was examined using stably transfected L cells in a PECAM-dependent aggregation assay. This adhesion was temperature sensitive and divalent cation dependent, with Mg2+ supporting aggregation to a greater degree than Ca2+. PECAM-dependent aggregation was heterophilic: PECAM-1 transfectants bound as readily to control-transfected L cells as to other PECAM-1 transfectants, demonstrating that a molecule endogenously expressed on the L cells serves as the ligand for PECAM in this system and presumably substitutes for the natural human ligand.

Bibliography

Muller, W. A., Berman, M. E., Newman, P. J., DeLisser, H. M., & Albelda, S. M. (1992). A heterophilic adhesion mechanism for platelet/endothelial cell adhesion molecule 1 (CD31). The Journal of Experimental Medicine, 175(5), 1401â1404.

Authors 5

W A Muller (first)
M E Berman (additional)
P J Newman (additional)
H M DeLisser (additional)
S M Albelda (additional)

References 0 Referenced 108

None

Dates

Type	When
Created	21 years, 2 months ago (June 24, 2004, 3:56 a.m.)
Deposited	2 years, 1 month ago (July 25, 2023, 12:42 a.m.)
Indexed	1 month, 1 week ago (July 24, 2025, 6:55 a.m.)
Issued	33 years, 4 months ago (May 1, 1992)
Published	33 years, 4 months ago (May 1, 1992)
Published Online	33 years, 4 months ago (May 1, 1992)
Published Print	33 years, 4 months ago (May 1, 1992)

Funders 0

None

BibTeX

@article{Muller_1992, title={A heterophilic adhesion mechanism for platelet/endothelial cell adhesion molecule 1 (CD31).}, volume={175}, ISSN={1540-9538}, url={http://dx.doi.org/10.1084/jem.175.5.1401}, DOI={10.1084/jem.175.5.1401}, number={5}, journal={The Journal of experimental medicine}, publisher={Rockefeller University Press}, author={Muller, W A and Berman, M E and Newman, P J and DeLisser, H M and Albelda, S M}, year={1992}, month=may, pages={1401–1404} }

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