DOI: 10.1084/jem.175.2.447. The beta subunit of the Fc epsilon RI is associated with the Fc gamma RIII on mast cells.

The beta subunit of the Fc epsilon RI is associated with the Fc gamma RIII on mast cells.

10.1084/jem.175.2.447

Crossref journal-article

Rockefeller University Press

The Journal of experimental medicine (291)

Abstract

Fc epsilon RI is a tetrameric receptor, composed of a ligand recognition subunit, alpha, a beta chain, and dimeric gamma chains. Previous studies have indicated that the dimeric gamma chain is associated with Fc gamma RIIIA (CD16) on natural killer cells and macrophages as well as the clonotypic T cell receptor. Here we show that in mast cells, in addition to the dimeric gamma chains, the beta subunit is associated not only with Fc epsilon RI, but also with Fc gamma RIIIA. Functional reconstitution studies with a mastocytoma cell line indicate that Fc gamma RIIIA composed of alpha, beta, and gamma subunits has the capacity for signal transduction. These studies suggest that through the association of alternative ligand recognition subunits (alpha epsilon, alpha gamma), a common signal transduction complex (beta gamma 2) mediates similar biochemical and effector functions in response to immunoglobulin G (IgG) and IgE.

Bibliography

Kurosaki, T., Gander, I., Wirthmueller, U., & Ravetch, J. V. (1992). The beta subunit of the Fc epsilon RI is associated with the Fc gamma RIII on mast cells. The Journal of Experimental Medicine, 175(2), 447â451.

Authors 4

T Kurosaki (first)
I Gander (additional)
U Wirthmueller (additional)
J V Ravetch (additional)

References 0 Referenced 62

None

Dates

Type	When
Created	21 years, 2 months ago (June 24, 2004, 3:56 a.m.)
Deposited	2 years, 1 month ago (July 24, 2023, 10:03 p.m.)
Indexed	5 months ago (March 30, 2025, 12:19 a.m.)
Issued	33 years, 6 months ago (Feb. 1, 1992)
Published	33 years, 6 months ago (Feb. 1, 1992)
Published Online	33 years, 6 months ago (Feb. 1, 1992)
Published Print	33 years, 6 months ago (Feb. 1, 1992)

Funders 0

None

BibTeX

@article{Kurosaki_1992, title={The beta subunit of the Fc epsilon RI is associated with the Fc gamma RIII on mast cells.}, volume={175}, ISSN={1540-9538}, url={http://dx.doi.org/10.1084/jem.175.2.447}, DOI={10.1084/jem.175.2.447}, number={2}, journal={The Journal of experimental medicine}, publisher={Rockefeller University Press}, author={Kurosaki, T and Gander, I and Wirthmueller, U and Ravetch, J V}, year={1992}, month=feb, pages={447–451} }

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