DOI: 10.1084/jem.174.5.1097. Antisense oligonucleotides from the stage-specific myeloid zinc finger gene MZF-1 inhibit granulopoiesis in vitro.

Antisense oligonucleotides from the stage-specific myeloid zinc finger gene MZF-1 inhibit granulopoiesis in vitro.

10.1084/jem.174.5.1097

Crossref journal-article

Rockefeller University Press

The Journal of experimental medicine (291)

Abstract

Zinc finger proteins are transcriptional regulators of other genes, often controlling developmental cascades of gene expression. A recently cloned zinc finger gene, MZF-1, was found to be preferentially expressed in myeloid cells. Using complementary radiolabeled MZF-1 RNA hybridized to human bone marrow smears in situ, it was discovered that the expression of MZF-1 is essentially limited to the myelocyte and metamyelocyte stages of granulopoiesis. Antisense but not sense oligonucleotides from MZF-1 significantly inhibited granulocyte colony-stimulating factor-driven granulocyte colony formation in vitro.

Bibliography

Bavisotto, L., Kaushansky, K., Lin, N., & Hromas, R. (1991). Antisense oligonucleotides from the stage-specific myeloid zinc finger gene MZF-1 inhibit granulopoiesis in vitro. The Journal of Experimental Medicine, 174(5), 1097â1101.

Authors 4

L Bavisotto (first)
K Kaushansky (additional)
N Lin (additional)
R Hromas (additional)

References 0 Referenced 59

None

Dates

Type	When
Created	21 years, 2 months ago (June 24, 2004, 3:56 a.m.)
Deposited	2 years, 1 month ago (July 24, 2023, 9:59 p.m.)
Indexed	3 months, 1 week ago (May 22, 2025, 3:11 a.m.)
Issued	33 years, 10 months ago (Nov. 1, 1991)
Published	33 years, 10 months ago (Nov. 1, 1991)
Published Online	33 years, 10 months ago (Nov. 1, 1991)
Published Print	33 years, 10 months ago (Nov. 1, 1991)

Funders 0

None

BibTeX

@article{Bavisotto_1991, title={Antisense oligonucleotides from the stage-specific myeloid zinc finger gene MZF-1 inhibit granulopoiesis in vitro.}, volume={174}, ISSN={1540-9538}, url={http://dx.doi.org/10.1084/jem.174.5.1097}, DOI={10.1084/jem.174.5.1097}, number={5}, journal={The Journal of experimental medicine}, publisher={Rockefeller University Press}, author={Bavisotto, L and Kaushansky, K and Lin, N and Hromas, R}, year={1991}, month=nov, pages={1097–1101} }

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