DOI: 10.1084/jem.174.3.745. Granulocyte/macrophage colony-stimulating factor and interleukin 3 release from human peripheral blood eosinophils and neutrophils.

Granulocyte/macrophage colony-stimulating factor and interleukin 3 release from human peripheral blood eosinophils and neutrophils.

10.1084/jem.174.3.745

Crossref journal-article

Rockefeller University Press

The Journal of experimental medicine (291)

Abstract

Human peripheral blood eosinophils released eosinophil survival-enhancing activity when stimulated with the calcium ionophore, ionomycin. The release of activity was detected as early as 3 h after stimulation and was inhibited by an immunomodulating agent, cyclosporin A. The survival-enhancing activity was completely abolished by treatment with anti-interleukin 3 (IL-3) and anti-granulocyte/macrophage colony-stimulating factor (GM-CSF) monoclonal antibodies. Moreover, IL-3 and GM-CSF were measurable in ionomycin-stimulated eosinophil supernatants by immunoassay. Eosinophils produced approximately one-half as much IL-3 and one-fifth as much GM-CSF as ionomycin-stimulated mononuclear cells. Neutrophils also produced IL-3 and GM-CSF, but the amounts were less than those produced by eosinophils. These observations suggest a novel role for eosinophils in pathophysiology of allergic inflammation and host defense mechanisms.

Bibliography

Kita, H., Ohnishi, T., Okubo, Y., Weiler, D., Abrams, J. S., & Gleich, G. J. (1991). Granulocyte/macrophage colony-stimulating factor and interleukin 3 release from human peripheral blood eosinophils and neutrophils. The Journal of Experimental Medicine, 174(3), 745â748.

Authors 6

H Kita (first)
T Ohnishi (additional)
Y Okubo (additional)
D Weiler (additional)
J S Abrams (additional)
G J Gleich (additional)

References 0 Referenced 232

None

Dates

Type	When
Created	21 years, 2 months ago (June 24, 2004, 3:56 a.m.)
Deposited	2 years, 1 month ago (July 24, 2023, 9:57 p.m.)
Indexed	1 month, 1 week ago (July 25, 2025, 6:40 a.m.)
Issued	34 years ago (Sept. 1, 1991)
Published	34 years ago (Sept. 1, 1991)
Published Online	34 years ago (Sept. 1, 1991)
Published Print	34 years ago (Sept. 1, 1991)

Funders 0

None

BibTeX

@article{Kita_1991, title={Granulocyte/macrophage colony-stimulating factor and interleukin 3 release from human peripheral blood eosinophils and neutrophils.}, volume={174}, ISSN={1540-9538}, url={http://dx.doi.org/10.1084/jem.174.3.745}, DOI={10.1084/jem.174.3.745}, number={3}, journal={The Journal of experimental medicine}, publisher={Rockefeller University Press}, author={Kita, H and Ohnishi, T and Okubo, Y and Weiler, D and Abrams, J S and Gleich, G J}, year={1991}, month=sep, pages={745–748} }

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