DOI: 10.1084/jem.173.3.775. Messenger RNA expression of the cytokine gene cluster, interleukin 3 (IL-3), IL-4, IL-5, and granulocyte/macrophage colony-stimulating factor, in allergen-induced late-phase cutaneous reactions in atopic subjects.

Messenger RNA expression of the cytokine gene cluster, interleukin 3 (IL-3), IL-4, IL-5, and granulocyte/macrophage colony-stimulating factor, in allergen-induced late-phase cutaneous reactions in atopic subjects.

10.1084/jem.173.3.775

Crossref journal-article

Rockefeller University Press

The Journal of experimental medicine (291)

Abstract

Cryostat sections from skin biopsies from 24-h allergen-induced late-phase cutaneous reactions (LPR) in 14 human atopic subjects were hybridized with 35S-labeled RNA probes for a number of cytokines. mRNA was detected for interleukin 3 (IL-3) (8/14), IL-4 (10/14), IL-5 (11/14), and granulocyte/macrophage colony-stimulating factor (GM-CSF) (13/14). Only 5 of 14 gave hybridization signals for IL-2, and 0 of 14 for interferon gamma. Biopsies from diluent controls gave only occasional weak signals. These results suggest that cells infiltrating the site of the 24-h LPR transcribe mRNA for the IL-3, IL-4, IL-5, and GM-CSF gene cluster and support the hypothesis that atopy is associated with preferential activation of cells having a similar cytokine profile to the murine T helper type 2 subset.

Bibliography

Kay, A. B., Ying, S., Varney, V., Gaga, M., Durham, S. R., Moqbel, R., Wardlaw, A. J., & Hamid, Q. (1991). Messenger RNA expression of the cytokine gene cluster, interleukin 3 (IL-3), IL-4, IL-5, and granulocyte/macrophage colony-stimulating factor, in allergen-induced late-phase cutaneous reactions in atopic subjects. The Journal of Experimental Medicine, 173(3), 775â778.

Authors 8

A B Kay (first)
S Ying (additional)
V Varney (additional)
M Gaga (additional)
S R Durham (additional)
R Moqbel (additional)
A J Wardlaw (additional)
Q Hamid (additional)

References 0 Referenced 489

None

Dates

Type	When
Created	21 years, 2 months ago (June 24, 2004, 3:56 a.m.)
Deposited	2 years, 1 month ago (July 24, 2023, 9:54 p.m.)
Indexed	1 month ago (Aug. 2, 2025, 12:48 a.m.)
Issued	34 years, 6 months ago (March 1, 1991)
Published	34 years, 6 months ago (March 1, 1991)
Published Online	34 years, 6 months ago (March 1, 1991)
Published Print	34 years, 6 months ago (March 1, 1991)

Funders 0

None

BibTeX

@article{Kay_1991, title={Messenger RNA expression of the cytokine gene cluster, interleukin 3 (IL-3), IL-4, IL-5, and granulocyte/macrophage colony-stimulating factor, in allergen-induced late-phase cutaneous reactions in atopic subjects.}, volume={173}, ISSN={1540-9538}, url={http://dx.doi.org/10.1084/jem.173.3.775}, DOI={10.1084/jem.173.3.775}, number={3}, journal={The Journal of experimental medicine}, publisher={Rockefeller University Press}, author={Kay, A B and Ying, S and Varney, V and Gaga, M and Durham, S R and Moqbel, R and Wardlaw, A J and Hamid, Q}, year={1991}, month=mar, pages={775–778} }

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